Prior Diagnosis of Barrett's Esophagus Is Infrequent, but Associated with Improved Esophageal Adenocarcinoma Survival.
Prior Diagnosis of Barrett's Esophagus Is Infrequent, but Associated with Improved Esophageal Adenocarcinoma Survival.
复制标题
DOI：
10.1007/s10620-018-5241-y
复制
发表时间：
2018-11
影响因子：
3.1
通讯作者：
Thrift AP
中科院分区：
文献类型：
--
作者：
Wenker TN;Tan MC;Liu Y;El-Serag HB;Thrift AP
Efforts to reduce mortality from esophageal adenocarcinoma (EA) have focused on screening and surveillance of Barrett’s esophagus (BE). We sought to determine the frequency of prior diagnosis of BE in patients with EA, and to evaluate the impact of a prior BE diagnosis on mortality in EA patients. This was a retrospective cohort study of patients diagnosed with EA in the VA during 2002–2016. We compared the distributions of EA stage and receipt of treatment between EA patients with and without a prior BE diagnosis and used Cox proportional hazards models to compare mortality risk (all-cause and cancer specific) unadjusted and adjusted for stage and treatment to assess their impact on any survival differences. Among 8564 EA patients, only 4.9% had a prior BE diagnosis. The proportion with prior BE diagnosis increased from 3.2% in EA patients diagnosed during 2005–2007 to 7.0% in those diagnosed during 2014–2016. EA patients with a prior BE diagnosis were more likely to have stage 1 disease and receive any treatment. A prior BE diagnosis was associated with lower all-cause mortality risk (hazard ratio [HR] unadjusted for stage, 0.69; 95% CI, 0.61–0.80), which was largely explained by the earlier stage of EA at the time of diagnosis (HR adjusted for stage, 0.87; 95% CI, 0.75–0.99). There was no evidence of lead time bias or length time bias. Prior diagnosis of BE was associated with better survival, largely due to earlier EA stage at diagnosis.
登录
查看更多内容
影响因子：
3.3
作者：
Sohn MW;Arnold N;Maynard C;Hynes DM
通讯作者：
Hynes DM
影响因子：
1.2
作者：
Zullig LL;Jackson GL;Dorn RA;Provenzale DT;McNeil R;Thomas CM;Kelley MJ
通讯作者：
Kelley MJ
影响因子：
29.4
作者：
Spechler SJ;Sharma P;Souza RF;Inadomi JM;Shaheen NJ;American Gastroenterological Association
通讯作者：
American Gastroenterological Association
影响因子：
24.5
作者：
El-Serag, Hashem B.;Naik, Aanand D.;Kramer, Jennifer R.
通讯作者：
Kramer, Jennifer R.
影响因子：
24.5
作者：
Bhat, Shivaram K.;McManus, Damian T.;Murray, Liam J.
通讯作者：
Murray, Liam J.