Quantitative Assessment of Lipiodol Deposition after Chemoembolization: Comparison between Cone-Beam CT and Multidetector CT
Quantitative Assessment of Lipiodol Deposition after Chemoembolization: Comparison between Cone-Beam CT and Multidetector CT
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DOI：
10.1016/j.jvir.2013.08.017
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发表时间：
2013-12-01
影响因子：
2.9
通讯作者：
Lin, MingDe
中科院分区：
文献类型：
--
作者：
Chen, Rongxin;Geschwind, Jean-Francois;Lin, MingDe
目的：评价经动脉化疗栓塞后直接进行cif锥形束计算机断层扫描（CBCT）评估乙碘油的能力（碘油）在肝细胞癌（HCC）中的沉积，并与未增强的多层螺旋CT（CT）进行比较。采用常规肝动脉化疗栓塞术治疗15例原发性肝癌，在经动脉化疗栓塞后直接进行CBCT以评估碘油沉积。经动脉化疗栓塞后24小时进行非增强多排CT。4例患者因肿瘤边缘或碘油沉积区域不清楚而被排除。采用ImageJ软件测量整个肿瘤和肝实质的图像增强密度，并计算肿瘤-肝对比度（TLC）。此外，通过半自动三维体积分割进行肿瘤和碘油的体积测量，并使用线性回归进行比较，以评估两种成像models.Results之间的一致性：CBCT上的TLC的平均值与多排CT上的TLC无显著差异（337.7 HU +/- 233.5 vs 283.0 HU +/- 152.1，P = 0.103）。整个肿瘤和仅碘油沉积区域的平均体积以及计算值。CBCT上碘油滞留的平均体积与多排CT相比无显著差异（肿瘤体积，9.6 cm（3）+/- 11.8 vs 10.8 cm（3）+/- 14.2，P = 0.142;碘油体积，6.3 cm（3）+/- 7.7 vs 7.0 cm（3）+/- 8.1，P = 0.214;碘油滞留百分比，68.9% +/- 24.0% vs 72.2% +/-23.1%，P = 0.578）。此外，肿瘤体积与碘油之间存在高度相关性。CBCT和多层螺旋CT（R-2 = 0.919和0.903）。结论：定量图像增强和体积分析表明，CBCT在评估肝细胞癌经动脉化疗栓塞后碘油沉积方面与多层螺旋CT相似。
Purpose: To evaluate the ability cif cone-beam computed tomography (CBCT) performed directly after transarterial chemoembolization to assess,ethiodized oil (Lipiodol) deposition in hepatocellular carcinoma (HCC) and compare it with unenhanced multidetector Computed tomography (CT).Materials and Methods: Conventional transarterial chemoembolization was used to treat 15 patients with HCC, and CBCT was performed to-assess Lipiodol deposition directly after transarterial chemoembolization. Unenhanced multidetector CT was-performed 24 hours after transarterial chemoembolization. Four patients were excluded because the margin of tumor or area of Lipiodol deposition-was unclear. The image enhancement density of the entire tumor and liver parenchyma was measured by ImageJ software, and tumor-to-liver contrast (TLC) was calculated. In addition, volumetric measurement of tumor and Lipiodol was performed by semiautomatic three-dimensional volume segmentation and compared using linear regression to evaluate consistency between the two imaging modalities.Results: The mean value of:TLC on CBCT was not significantly different from TLC on multidetector CT (337.7 HU +/- 233.5 vs 283.0 HU +/- 152.1, P =.103). The average volume of the whole tumor and of only the regions with Lipiodol deposition and the calculated. average percentage-of Lipiodol retention on CBCT Were not Significantly different compared with multidetector CT (tumor volume, 9.6 cm(3) +/- 11.8 vs 10.8 cm(3) +/- 14.2, P = .142; Lipiodol volume, 6.3 cm(3) +/- 7.7 vs 7.0 cm(3) +/- 8.1, P = .214; percentage of Lipiodol retention, 68.9% +/- 24.0% vs 72.2% +/- 23.1%, P = .578). Additionally, there was a high correlation in the volume of tumor and Lipiodol between. CBCT and multidetector CT (R-2 = 0.919 and 0.903).Conclusions: The quantitative image enhancement and volume analyses demonstrate that CBCT is similar to multidetector CT in assessing Lipiodol deposition in HCC after transarterial chemoembolization.