Structure and function of 5S rRNA in the ribosome
Structure and function of 5S rRNA in the ribosome
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DOI：
10.1139/o95-094
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发表时间：
1995-11-01
影响因子：
2.9
通讯作者：
Lavrik, IN
中科院分区：
文献类型：
--
作者：
Bogdanov, AA;Dontsova, OA;Lavrik, IN
5S rRNA是一种小的RNA分子，是几乎所有活着的生物体核糖体的组成部分。本文讨论了5S rRNA的生物发生及其作为核糖体的一个独立结构域的性质，以及关于5S rRNA在游离态及其与核糖体蛋白的络合物中的高阶结构及其在核糖体中的折叠的最新概念。特别关注最近在5S rRNA研究中有用的实验方法。详细讨论了我们自己关于核糖体中5S rRNA的拓扑结构的数据。讨论了描述5S rRNA在核糖体功能中可能的功能作用的假设。
5S rRNA is a small RNA molecule that is a component of a ribosome from almost all living organisms. In this review, we discuss the biogenesis of 5S rRNA and its properties as an independent structural domain of a ribosome as well as the current concepts concerning the higher order structure of 5S rRNA in free state and in its complexes with ribosomal proteins and its folding in the ribosome. Special attention is paid to recent experimental approaches that have been useful in 5S rRNA studies. Our own data on topography of 5S rRNA in the ribosomes are discussed in detail. The hypothesis describing the possible functional role of 5S rRNA for ribosome functioning is discussed.