Steady magnetic fields effect on lipid peroxidation kinetics.
Steady magnetic fields effect on lipid peroxidation kinetics.
复制标题
稳定磁场对脂质过氧化动力学的影响。
DOI：
10.1080/13510002.1994.11746959
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
O. M. Mikhailik
中科院分区：
文献类型：
--
作者：
U. Lalo;Y. Pankratov;O. M. Mikhailik
稳定磁场（范围从 0 至 280 mT）对模型系统中发生的非酶脂质过氧化动力学的影响进行了研究，该模型系统由通过耗氧从 1, 2-二油酰磷脂酰胆碱获得的脂质体组成。发现弱稳定磁场会加速该过程。采用计算机模拟方法来检测控制过程动力学的反应，阐明磁敏阶段（铁（III）的引发和还原，以及脂质过氧化物自由基重组）并确定它们在各种外部磁场下的速率常数。脂质细胞膜的过氧化动力学已在接近细胞内的氧和“游离”铁浓度以及在不同的外部磁场值下增加的游离铁浓度下进行了数学建模。
The effect of steady magnetic fields (ranging from 0 to 280 mT) has been investigated on the kinetics of non-enzymatic lipid peroxidation occurring in a model system consisting of liposomes obtained from 1, 2-dioleoylphosphatidylcholine by oxygen consumption. The process was found to be accelerated by weak steady magnetic fields. A computer simulation method was employed to detect the reactions that govern the process kinetics, to elucidate magneto-sensitive stages (initiation and reduction of iron(III), as well as lipid peroxide radical recombination) and to determine their rate constants at various external magnetic fields. The kinetics of peroxidation of lipid cell membranes have been modeled mathematically at oxygen and 'free' iron concentrations close to those in the cells and also at increased free iron concentrations at different external magnetic field values.