Influences of gender on sympathetic nerve responses to static exercise
Influences of gender on sympathetic nerve responses to static exercise
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DOI：
10.1152/jappl.1996.80.1.245
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发表时间：
1996-01-01
影响因子：
3.3
通讯作者：
Sinoway, LI
中科院分区：
文献类型：
--
作者：
Ettinger, SM;Silber, DH;Sinoway, LI
我们比较了26名未经训练的男性(平均年龄35岁+/-3岁)和23名未经训练的女性(平均年龄39岁+/-4岁)在30%最大自愿收缩(MVC)时对静态握手的反射反应。与男性相比，女性在血压和肌肉交感神经活动(MSNA；通过显微神经学检查)方面的增加有所减弱。这种差异在握力后循环停止期间也观察到了。(31)核磁共振波谱研究表明，与男性相比，女性的二质子化磷酸盐的产生和细胞酸中毒的发展都有所减弱。受试者还进行缺血握手以缓解疲劳。在这个范例中，两组的MSNA反应相似，表明自由灌流的条件是充分表达性别效应所必需的。最后，我们检查了7名男性(26岁+/-1岁)和6名女性(25岁+/-2岁)对拇收肌锻炼的MSNA反应。两组的MVC值和疲劳时间相似(MVC：男性4.3+/-0.4 kg；女性4.0+/-0.3 kg；无统计学意义。疲劳时间：男子209+/-16 S；女子287+/-50 S；无统计学意义)。在运动结束和运动后停循环期间，与男性相比，女性的MSNA反应减弱。我们的结论是，在非缺血性静态运动中，女性的交感神经流出比男性少。这种反应是由于女性代谢性反射减弱所致。最后，在拇内收肌实验的基础上，这种效应似乎与肌肉质量、工作负荷和训练水平无关。
We compared reflex responses to static handgrip at 30% maximal voluntary contraction (MVC) in 26 untrained men (mean age 35 +/- 3 yr) and 23 untrained women (mean age 39 +/- 4 yr). Women demonstrated attenuated increases in blood pressure and muscle sympathetic nerve activity (MSNA; by microneurography) compared with men. This difference was also observed during a period of posthandgrip circulatory arrest. (31)p-nuclear magnetic resonance (NMR) spectroscopy studies demonstrated attenuations in the production of diprotonated phosphate and the development of cellular acidosis in women compared with men. Subjects also performed ischemic handgrip to fatigue. During this paradigm, MSNA responses were similar in the two groups, suggesting that freely perfused conditions are necessary for the full expression of the gender effect. Finally, we examined MSNA responses to adductor pollicus exercise in 7 men (26 +/- 1 yr) and 6 women (25 +/- 2 yr). MVC values and times to fatigue were similar in the two groups (MVC: men, 4.3 +/- 0.4 kg; women, 4.0 +/- 0.3 kg; not significant. Time to fatigue: men, 209 +/- 16 s; women, 287 +/- 50 s; not significant). At periods of end exercise and postexercise circulatory arrest, MSNA responses were attenuated in the women compared with the men. We conclude that, during nonischemic static exercise, sympathetic neural outflow is less in women compared with men. This response is due to an attenuated metaboreflex in women. Finally, on the basis of the adductor pollicus experiments, this effect appears independent of muscle mass, workload, and the level of training.