Developing drugs for core social and communication impairment in autism
Developing drugs for core social and communication impairment in autism
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DOI：
10.1016/j.chc.2008.06.010
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发表时间：
2008-10-01
影响因子：
2.4
通讯作者：
McDougle, Christopher J.
中科院分区：
文献类型：
--
作者：
Posey, David J.;Erickson, Craig A.;McDougle, Christopher J.
研究药物对自闭症核心社会和语言障碍的影响存在许多挑战。药物如芬氟拉明、纳洛酮和促胰液素似乎对这些核心症状无效。利培酮在治疗自闭症的易怒时，在社会关系的某些方面有所改善。对于选择性5-羟色胺再摄取抑制剂、胆碱能药物、多巴胺能药物和催产素对核心自闭症症状的效用，还需要进行更多的研究。
There are many challenges to studying drug effects on core social and language impairment in autism. Drugs such as fenfluramine, naltrexone, and secretin do not appear to be efficacious for these core symptoms. Risperidone has led to improvement in some aspects of social relatedness when used to treat irritability in autism. More research is needed on the utility of selective serotonin reuptake inhibitors, cholinergic drugs, glutamatergic drugs, and oxytocin for core autistic symptoms.