The Role of Lytic Infection for Lymphomagenesis of Human γ-Herpesviruses.
The Role of Lytic Infection for Lymphomagenesis of Human γ-Herpesviruses.
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裂解感染对人 γ-疱疹病毒淋巴瘤发生的作用。
DOI：
10.3389/fcimb.2021.605258
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发表时间：
2021
影响因子：
5.7
通讯作者：
Münz C
中科院分区：
文献类型：
--
作者：
Münz C
爱泼斯坦巴尔病毒（EBV）和卡波西肉瘤相关疱疹病毒（KSHV）是两种致癌的人类γ-疱疹病毒，其各自与1-2%的人类肿瘤相关。它们编码真正的致癌基因，在潜伏感染期间表达，以扩增宿主细胞和其中的自身。相比之下，产生裂解病毒颗粒的感染被认为破坏宿主细胞，甚至可能被诱导以治疗性地消除EBV和KSHV相关的肿瘤。然而，近年来已经变得明显的是，早期裂解复制支持这两种人类致癌病毒的肿瘤发生。这篇综述将讨论这种范式变化的证据，以及裂解基因产物如何调节微环境以促进EBV和KSHV相关的肿瘤发生。
Epstein Barr virus (EBV) and Kaposi sarcoma associated herpesvirus (KSHV) are two oncogenic human γ-herpesviruses that are each associated with 1-2% of human tumors. They encode bona fide oncogenes that they express during latent infection to amplify their host cells and themselves within these. In contrast, lytic virus particle producing infection has been considered to destroy host cells and might be even induced to therapeutically eliminate EBV and KSHV associated tumors. However, it has become apparent in recent years that early lytic replication supports tumorigenesis by these two human oncogenic viruses. This review will discuss the evidence for this paradigm change and how lytic gene products might condition the microenvironment to facilitate EBV and KSHV associated tumorigenesis.