Prism adaptation changes resting-state functional connectivity in the dorsal stream of visual attention networks in healthy adults: A fMRI study
Prism adaptation changes resting-state functional connectivity in the dorsal stream of visual attention networks in healthy adults: A fMRI study
复制标题
棱镜适应改变了健康成年人视觉注意网络背侧流的静息态功能连接：一项功能磁共振成像研究
DOI：
10.1016/j.cortex.2018.10.018
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发表时间：
2019
期刊：
影响因子：
3.6
通讯作者：
Liu Meigen
中科院分区：
文献类型：
--
作者：
Tsujimoto Kengo;Mizuno Katsuhiro;Nishida Daisuke;Tahara Masatoshi;Yamada Emi;Shindo Shiori;Kasuga Shoko;Liu Meigen
单侧空间忽略（USN）可以定义为在没有感觉或运动缺陷的情况下，无法定向到对损伤的刺激。尽管棱镜适应（PA）的行为和临床效应已被广泛接受，但其潜在机制仍存在争议。然而，最近的神经影像学和神经生理学研究支持的想法，PA影响视觉注意和感觉运动网络，包括顶叶皮层和小脑。我们研究了PA对注意和感觉运动网络功能连接（FC）的影响，使用功能磁共振成像（fMRI）评估健康个体PA前后静息状态FC的变化。在PA前、PA后（Post 1）和PA后1小时（Post 2）进行MR检查。右额眼（FEF）视野与右顶内沟之间的FC在PA后1显著降低，右FEF视野与右前扣带回之间的FC在PA后1 h显著升高，并在1 h内恢复。这是第一个研究证明短暂的变化，静息状态FC的右背注意网络（DAN）的PA在健康成人使用功能磁共振成像。这些结果将有助于阐明PA治疗的潜在机制，并为USN和/或其他高级皮质功能障碍设计新的治疗方法。
Unilateral spatial neglect (USN) can be defined as a failure to orient to contra-lesional stimuli in the absence of either sensory or motor defects. Although the behavioral and clinical effects of prism adaptation (PA) are widely accepted, its underlying mechanisms are still controversial. However, recent neuroimaging and neurophysiological studies support the idea that PA affects the visual attention and sensorimotor networks including in the parietal cortex and cerebellum. We investigate the effect of PA on functional connectivity (FC) in attention and sensorimotor networks, evaluating changes of resting-state FC before and after PA in healthy individuals using functional magnetic resonance imaging (fMRI). MR sessions were conducted before PA, after PA (Post1), and 1 h after PA (Post2). The FC between the right frontal eye (FEF) field and the right intraparietal sulcus was significantly decreased at Post1 and that between the right FEF and the right anterior cingulate cortex was significantly increased after PA and recovered within 1 h. This is the first study to demonstrate transient changes of resting-state FC in the right dorsal attention network (DAN) by PA in healthy adults using fMRI. These results will contribute to the elucidation of the underling mechanism of PA therapy and to devising new therapies for USN and/or other higher cortical dysfunctions.