Chimpanzee Personality and the Arginine Vasopressin Receptor 1A Genotype.
Chimpanzee Personality and the Arginine Vasopressin Receptor 1A Genotype.
复制标题
DOI：
10.1007/s10519-016-9822-2
复制
发表时间：
2017-03
影响因子：
2.6
通讯作者：
Inoue-Murayama M
中科院分区：
文献类型：
--
作者：
Wilson VA;Weiss A;Humle T;Morimura N;Udono T;Idani G;Matsuzawa T;Hirata S;Inoue-Murayama M
精氨酸加压素受体1a（AVPR 1a）基因的多态性与人类社会行为相关的各种指标有关，包括兄弟姐妹冲突和宜人性。在黑猩猩中，AVPR 1a多态性与社会互动的重要特征相关，包括社交性，联合注意力，支配地位，忠诚度和等级人格维度，称为低α/稳定性，去抑制和负面情绪/低支配地位。我们研究了AVPR 1a和六个人格领域和等级人格维度之间的关联，在129只黑猩猩（Pan troglodytes）生活在日本或在几内亚的避难所。我们拟合了三个线性模型和三个动物模型。第一个模型包括基因型，第二个包括性别和基因型，第三个包括基因型，性别和性别×基因型。所有的人格表型都是可遗传的。拥有长型等位基因的黑猩猩在遗传上更高，但仅在不包括其他预测因子的模型中;然而，额外的分析表明，这可能是研究设计的结果。在包括性别和性别×基因型的动物模型中，等位基因短型纯合子的黑猩猩具有更高的外倾性。结合之前对黑猩猩和人类的研究结果，与攻击性相关的发现表明，AVPR 1a可能与较低水平的冲动攻击有关。AVPR 1a基因型与外倾性之间的关联方向与人们预期的AVPR 1a与社会行为相关的方向相反。这些结果有助于我们进一步了解黑猩猩个性的遗传基础。本文的在线版本（doi：10.1007/s10519-016-9822-2）包含补充材料，可供授权用户使用。
Polymorphisms of the arginine vasopressin receptor 1a (AVPR1a) gene have been linked to various measures related to human social behavior, including sibling conflict and agreeableness. In chimpanzees, AVPR1a polymorphisms have been associated with traits important for social interactions, including sociability, joint attention, dominance, conscientiousness, and hierarchical personality dimensions named low alpha/stability, disinhibition, and negative emotionality/low dominance. We examined associations between AVPR1a and six personality domains and hierarchical personality dimensions in 129 chimpanzees (Pan troglodytes) living in Japan or in a sanctuary in Guinea. We fit three linear and three animal models. The first model included genotype, the second included sex and genotype, and the third included genotype, sex, and sex × genotype. All personality phenotypes were heritable. Chimpanzees possessing the long form of the allele were higher in conscientiousness, but only in models that did not include the other predictors; however, additional analyses suggested that this may have been a consequence of study design. In animal models that included sex and sex × genotype, chimpanzees homozygous for the short form of the allele were higher in extraversion. Taken with the findings of previous studies of chimpanzees and humans, the findings related to conscientiousness suggest that AVPR1a may be related to lower levels of impulsive aggression. The direction of the association between AVPR1a genotype and extraversion ran counter to what one would expect if AVPR1a was related to social behaviors. These results help us further understand the genetic basis of personality in chimpanzees. The online version of this article (doi:10.1007/s10519-016-9822-2) contains supplementary material, which is available to authorized users.