Lipid composition changes in normal breast throughout the menstrual cycle
Lipid composition changes in normal breast throughout the menstrual cycle
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DOI：
10.1007/bf02592240
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发表时间：
1997-06-01
影响因子：
2.3
通讯作者：
Bolinger, L
中科院分区：
文献类型：
--
作者：
Dzendrowskyj, TE;Noyszewski, EA;Bolinger, L
使用磁共振成像 (MRI) 检测女性乳腺癌越来越多地用作 X 射线乳房 X 光检查的补充。此外，质子磁共振波谱 (H-1 MRS) 已检测到与人体活检组织中肿瘤发生和进展相关的脂质谱的变化。由于正常的“静止”乳房高度活跃，因此有必要考虑到脂质谱中观察到的任何变化可能并不表明乳腺肿瘤的发生。本研究的目的是使用 4.0 T 的 MRS 评估“正常人”在整个月经周期中乳房脂质成分的变化。五名没有已知乳腺疾病史的女性每两周接受一次 MRS 乳房检查。 MRS 结果显示水和脂肪共振揭示了整个月经周期期间脂质含量的周期性变化。特别是，亚甲基 (-CH2-) 和烯丙基亚甲基 (CH2CH2*CH=) 共振分别在 2.1 ppm 和 1.3 ppm 处观察到强度变化。这些强度变化假定每个受试者在 28 天内具有类似的循环趋势，与月经周期的卵泡期、排卵期和黄体期相关。获得的结果可以表明月经周期期间乳房中的细胞合成或代谢活动，并提供与乳腺疾病相关的脂质反应相关的有价值的信息。
The detection of breast cancer in women using magnetic resonance imaging (MRI) is increasingly used as a supplement to X-ray mammography. Furthermore, proton MR spectroscopy (H-1 MRS) has detected alterations in lipid profiles that are Linked with tumor development and progression in human biopsy tissue. Because normal ''resting'' breast is highly active, it is necessary to consider that any alterations observed in lipid profiles may not be indicative of breast tumor development. The purpose of this study was to assess the changes in lipid composition in the breast throughout the menstrual cycle in ''normals'' using MRS at 4.0 T. Five women with no known history of breast disease were subject to biweekly MRS breast examinations. MRS results showing water and fat resonances revealed cyclic changes in the Lipid content throughout the duration of the menstrual cycle. In particular, intensity changes were seen in methylene (-CH2-) and allylic methylene (CH2CH2*CH=) resonances at 2.1 ppm and 1.3 ppm, respectively. These intensity changes assumed a similar cyclic trend for each subject over the 28 days that correlate with the follicular, ovulatory, and luteal phases of the menstrual cycle. The results obtained may indicate cell synthesis or metabolic activity in the breast during the menstrual cycle and provide valuable information pertinent to lipid responses associated with breast disease.