Harvest of microbial suspensions by microfiltration
Harvest of microbial suspensions by microfiltration
复制标题
通过微滤收获微生物悬浮液
DOI：
10.1016/0011-9164(90)85027-8
复制
发表时间：
1990
期刊：
影响因子：
9.9
通讯作者：
M. Kula
中科院分区：
文献类型：
--
作者：
B. Riesmeier;K. Kroner;M. Kula
测试了描述微生物悬浮液错流过滤过程中通量的数学模型的适用性，以预测放大过程中商业模块的性能。对于过滤面积高达1 m2的模块，通量可以在约20%的置信区间内计算，这些模块与用于生成模型开发数据集的自建实验室管状和扁平通道单元具有相似的设计。然而，在旋转过滤器中，观察到的通量显著高于计算值，这归因于在膜表面产生剪切的不同模式。该数学模型仅适用于常规模块。有了这个限制，它可以作为一个多功能的工具来评估和扩大错流过滤的微生物悬浮液的收获。
The applicability of a mathematical model describing flux during cross-flow filtration of microbial suspensions was tested, to predict performance of commercial modules during scale up. Flux could be calculated within the confidence interval of about 20% for modules up to 1 m2filter area, which are of similiar design as the self-built laboratory tubular and flat channel units utilized to generate the data set for the development of the model. In a rotating filter, however, observed flux was significantly higher than calculated, which is attributed to the different mode to generate shear at the membrane surface. The mathematical model is valid only for conventional modules. With this restriction it can used as a versatile tool to evaluate and scale up cross-flow filtration for the harvest of microbial suspensions.