MOLECULAR-BIOLOGY OF THE HEPATITIS-C VIRUSES - IMPLICATIONS FOR DIAGNOSIS, DEVELOPMENT AND CONTROL OF VIRAL DISEASE
MOLECULAR-BIOLOGY OF THE HEPATITIS-C VIRUSES - IMPLICATIONS FOR DIAGNOSIS, DEVELOPMENT AND CONTROL OF VIRAL DISEASE
复制标题
DOI：
10.1016/0270-9139(91)91430-9
复制
发表时间：
1991-08-01
期刊：
影响因子：
13.5
通讯作者：
CHOO, QL
中科院分区：
文献类型：
--
作者：
HOUGHTON, M;WEINER, A;CHOO, QL
最近用重组互补DNA方法发现了一种非甲、非乙型肝炎病毒的基因组[1]。它被称为丙型肝炎病毒(丙型肝炎病毒)，并开发了一种特异性的诊断工具，以循环的丙型肝炎病毒抗体(抗HCVI)是利用从表达丙型肝炎病毒基因组小部分的重组酵母中提取的纯化病毒多肽开发的(2)。使用这种免疫分析方法获得的大量数据表明，丙型肝炎病毒是世界各地输血后NANB肝炎的主要原因。抗-HCV与美国(2，8)和西欧(4.9，10)的大多数社区获得性NANB肝炎病例有关，是意大利不明原因慢性肝病的主要原因(11)。此外，抗-丙型肝炎病毒与日本(12,131例，意大利110例)和西班牙(14例)的大多数肝细胞癌病例有关。因此，丙型肝炎病毒是世界各地NANB肝炎、慢性肝病和肝细胞癌的主要病原体。本文综述了丙型肝炎病毒的分子生物学，并讨论了其在诊断中的意义。治疗和控制丙型肝炎。
The genome of a non-A, non-B INANB, hepatitis virus was discovered recently using a recombinant complementary DNA (cDNA) approach (1). It was termed the hepatitis C virus (HCV), and a specific diagnostic tool for circulating HCV antibody (anti-HCVI was developed using purified viral polypeptide derived from recombinant yeast expressing a small part of the HCV genome (2). Numerous data obtained using this immunoassay indicate that HCV is the predominant cause of posttransfusion NANB hepatitis around the world 12-7). Anti-HCV is associated with most community-acquired NANB hepatitis cases in the United States (2, 8) and Western Europe (4. 9, 10) and is a major cause of cryptogenic chronic liver disease in Italy (11). In addition, anti-HCV is associated with most cases of HCC in Japan (12, 131, Italy 110) and Spain (14). Hence, HCV is a major etiological agent of NANB hepatitis, chronic liver disease and HCC around the world. This article reviews the molecular biology of HCV and discusses its implications in diagnosing. treating and controlling HCV disease.