Influence of endurance training on central sympathetic outflow to skeletal muscle in response to a mixed meal.
Influence of endurance training on central sympathetic outflow to skeletal muscle in response to a mixed meal.
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耐力训练对混合膳食反应中枢交感神经流出骨骼肌的影响。
DOI：
10.1152/japplphysiol.01174.2009
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Fadel,PaulJ
中科院分区：
文献类型：
--
作者：
Young,ColinN;Deo,ShekharH;Kim,Areum;Horiuchi,Masahiro;Mikus,CatherineR;Uptergrove,GraceM;Thyfault,JohnP;Fadel,PaulJ
营养摄入伴随着中枢交感神经流出的增加，这种反应主要归因于胰岛素。在胰岛素抵抗的情况下，胰岛素介导的交感兴奋似乎被钝化，这表明除了外周胰岛素不敏感外，这种情况还可能损害胰岛素在介导交感神经激活中的中枢作用。目前尚不清楚的是，胰岛素敏感状态，如长期耐力训练引起的状态，是否会改变餐后条件下胰岛素的中枢交感神经效应。为探讨这一问题，对11名高体能男性[HF；峰值摄氧量(V̇O2峰值)65.9±1.4ml·kg−1·min−1]和9名中等体能男性(AF；V̇o2Peak43.6±1.3ml·kg−1·−1)在摄入混合餐饮前和后12 0min的血浆胰岛素、血糖、肌交感神经活性、心率和动脉压进行了测定。正如预期的那样，HF组的胰岛素摄入反应低于AF组(0-120曲线下的胰岛素面积：2,314±171vs.4,028±460μIU·ml−1·120−1，HF组与AF组，P<；0.05)，两组之间的血糖反应相似。重要的是，在进食后，心力衰竭受试者比房颤受试者表现出更大的MSNA升高(例如，120min：Δ21±1比8±3脉搏/100次心跳，心衰比房颤，P<；0.05)。此外，当相对于血浆胰岛素表达时，心力衰竭受试者的MSNA对于任何给定的胰岛素变化都表现出更大的变化。两组进食后的动脉血压反应相似。总而言之，这些数据表明，除了改善外周胰岛素敏感性外，耐力训练可能会增强胰岛素的中枢交感神经效应，从而在食用混合餐后增加MSNA。
Nutrient intake is accompanied by increases in central sympathetic outflow, a response that has been mainly attributed to insulin. Insulin-mediated sympathoexcitation appears to be blunted in insulin-resistant conditions, suggesting that aside from peripheral insulin insensitivity, such conditions may also impair the central action of insulin in mediating sympathetic activation. What remains unclear is whether an insulin-sensitive state, such as that induced by chronic endurance training, alters the central sympathetic effects of insulin during postprandial conditions. To examine this question plasma insulin and glucose, muscle sympathetic nerve activity (MSNA), heart rate, and arterial blood pressure were measured in 11 high-fit [HF; peak oxygen uptake (V̇o2peak) 65.9 ± 1.4 ml·kg−1·min−1] and 9 average-fit (AF; V̇o2peak43.6 ± 1.3 ml·kg−1·min−1) male subjects before and for 120 min after ingestion of a mixed meal drink. As expected, the insulin response to meal ingestion was lower in HF than AF participants (insulin area under the curve0–120: 2,314 ± 171 vs. 4,028 ± 460 μIU·ml−1·120−1, HF vs. AF,P< 0.05), with similar plasma glucose responses between groups. Importantly, following consumption of the meal, the HF subjects demonstrated a greater rise in MSNA compared with the AF subjects (e.g., 120 min: Δ21 ± 1 vs. 8 ± 3 bursts/100 heart beats, HF vs. AF,P< 0.05). Furthermore, when expressed relative to plasma insulin, HF subjects exhibited a greater change in MSNA for any given change in insulin. Arterial blood pressure responses following meal intake were similar between groups. Collectively, these data suggest that, in addition to improved peripheral insulin sensitivity, endurance training may enhance the central sympathetic effect of insulin to increase MSNA following consumption of a mixed meal.
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影响因子：
--
作者：
MARETTE, A;BUKOWIECKI, LJ
通讯作者：
BUKOWIECKI, LJ
前腹侧第三脑室病变消除了腰部交感神经对胰岛素的反应。
DOI：
10.1161/01.hyp.23.6.1059
发表时间：
1994
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Muntzel,M;Beltz,T;Mark,AL;Johnson,AK
通讯作者：
Johnson,AK
脑室内胰岛素使交感神经活动产生不均匀的区域性增加。
DOI：
10.1152/ajpregu.1994.267.5.r1350
发表时间：
1994
期刊：
The American journal of physiology
影响因子：
--
作者：
Muntzel,MS;Morgan,DA;Mark,AL;Johnson,AK
通讯作者：
Johnson,AK
DOI：
10.1172/jci21737
发表时间：
2004-09
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
K. Rahmouni;D. Morgan;Gina Morgan;Xuebo Liu;C. Sigmund;A. Mark;W. Haynes
通讯作者：
K. Rahmouni;D. Morgan;Gina Morgan;Xuebo Liu;C. Sigmund;A. Mark;W. Haynes
影响因子：
15.9
作者：
ANDERSON, EA;HOFFMAN, RP;MARK, AL
通讯作者：
MARK, AL