Genetic control of responses to Trypanosoma cruzi in mice: multiple genes influencing parasitemia and survival
Genetic control of responses to Trypanosoma cruzi in mice: multiple genes influencing parasitemia and survival
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小鼠对克氏锥虫反应的基因控制：影响寄生虫血症和生存的多个基因
DOI：
10.1128/iai.36.2.637-644.1982
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发表时间：
1982
影响因子：
3.1
通讯作者：
James Watson
中科院分区：
文献类型：
--
作者：
Ruth;Wrightsman;Stuart Krassner;James Watson
根据注射克氏锥虫（秘鲁）的10（3）个锥鞭毛体后产生的寄生虫血症水平，可将近交系小鼠分为两组。到第17天出现寄生虫血症的菌株（包括C3 H/HeJ、BALB/c和CBA/N小鼠）超过10（7）个锥虫鞭毛虫/ml，称为高寄生虫血症菌株。低寄生虫血症品系，包括C57 BL/6 J和DBA/2 J小鼠，在感染第17天产生低于5 x 10（6）个锥鞭虫/ml的寄生虫血症。用10（3）个锥虫鞭毛体注射来自C57 BL/10 J、C57 BL/6 J和BALB/c背景（在H-2区域不同）的同源小鼠，以确定H-2基因座对感染应答的影响。H-2位点对感染过程中获得的寄生虫血症水平没有影响。然而，一种菌株B10.S（H-2s）是不寻常的，因为大多数小鼠在感染后存活。用T. cruzi（秘鲁）提出，低寄生虫血症应答以显性方式遗传，并且存活可能受几个其它基因的影响。对T.通过寄生虫血症和存活时间测量，近交系小鼠的克氏感染受几个基因影响。一个或多个基因，位于H-2区域之外，参与调节感染期间达到的寄生虫血症水平。另一个H-2连锁基因参与感染的存活，似乎是H-2s单倍型所独有的。
Inbred strains of mice can be divided into two groups based on the level of parasitemia which develops after injection with 10(3) trypomastigotes of Trypanosoma cruzi (Peru). Strains which developed parasitemias of greater than 10(7) trypomastigotes per ml by day 17, including C3H/HeJ, BALB/c, and CBA/N mice, were termed high parasitemia strains. Low parasitemia strains, including C57BL/6J and DBA/2J mice, developed parasitemias of less than 5 x 10(6) trypomastigotes per ml by day 17 of infection. Congenic mice from C57BL/10J, C57BL/6J, and BALB/c backgrounds which differed at the H-2 region were injected with 10(3) trypomastigotes to determine the effect of the H-2 locus on response to infection. The H-2 locus had no effect on the level of parasitemia attained during infection. However, one strain, B10.S (H-2s), was unusual in that most of the mice survived infection. The results of infection of F1 hybrid progeny with T. cruzi (Peru) suggest that the low parasitemia response in inherited in a dominant manner and that survival may be influenced by several other genes. The response to T. cruzi infection in inbred mice, as measured by parasitemia and survival time, was influenced by several genes. One or more genes, located outside the H-2 region, were involved in regulating the level of parasitemia reached during infection. Another H-2-linked gene(s) was involved in survival of the infection and appeared to be unique to the H-2s haplotype.
小鼠1号染色体。
DOI：
10.1007/s003359901120
发表时间：
1999
期刊：
Mammalian genome : official journal of the International Mammalian Genome Society
影响因子：
--
作者：
Seldin,MF
通讯作者：
Seldin,MF