Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis.
Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis.
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DOI：
10.3390/ijms17010087
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发表时间：
2016-01-12
影响因子：
5.6
通讯作者：
Suzuki R
中科院分区：
文献类型：
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作者：
Kumagai K;Horikawa T;Shigematsu H;Matsubara R;Kitaura K;Eguchi T;Kobayashi H;Nakasone Y;Sato K;Yamada H;Suzuki S;Hamada Y;Suzuki R
金属通常会引起迟发型超敏反应，这可能是通过在发炎的皮肤中积累T细胞介导的，称为刺激性或过敏性接触性皮炎。然而，由于没有合适的动物模型，在金属过敏的发展过程中积累的T细胞的特征很差。我们以前建立了新的金属过敏小鼠模型，并发现金属特异性T细胞和自然杀伤（NK）T细胞在发炎的皮肤中的积累。在我们的金属过敏的新模型中，皮肤超敏反应是通过向小鼠腹股沟给予金属氯化物和脂多糖，然后在足垫中进行金属氯化物挑战，通过重复致敏诱导的。这些模型使我们能够研究炎症皮肤中金属过敏的免疫反应的确切机制。在这篇综述中，我们总结了金属过敏的几种小鼠模型的免疫反应，并描述了在过敏性接触性皮炎的T细胞受体方面的抗原特异性反应发生在发炎的皮肤。此外，我们认为在金属离子诱导的过敏性接触性皮炎的免疫调节积累的NK T细胞。
Metal often causes delayed-type hypersensitivity reactions, which are possibly mediated by accumulating T cells in the inflamed skin, called irritant or allergic contact dermatitis. However, accumulating T cells during development of a metal allergy are poorly characterized because a suitable animal model is unavailable. We have previously established novel murine models of metal allergy and found accumulation of both metal-specific T cells and natural killer (NK) T cells in the inflamed skin. In our novel models of metal allergy, skin hypersensitivity responses were induced through repeated sensitizations by administration of metal chloride and lipopolysaccharide into the mouse groin followed by metal chloride challenge in the footpad. These models enabled us to investigate the precise mechanisms of the immune responses of metal allergy in the inflamed skin. In this review, we summarize the immune responses in several murine models of metal allergy and describe which antigen-specific responses occur in the inflamed skin during allergic contact dermatitis in terms of the T cell receptor. In addition, we consider the immune regulation of accumulated NK T cells in metal ion–induced allergic contact dermatitis.