Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy
Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy
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DOI：
10.1136/jnnp.2005.075713
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发表时间：
2006-04-01
影响因子：
11
通讯作者：
Perani, D
中科院分区：
文献类型：
--
作者：
Padovani, A;Borroni, B;Perani, D
背景资料：进行性核上性麻痹（progressive supranuclear palsy，PSP）是仅次于帕金森病的第二大锥体外系综合征，其灰质和白色改变的综合特征至今仍不清楚。目的：分别应用基于体素的形态计量学（voxel based morphometry，VBM）和扩散张量成像（diffusion tensor imaging，DTI）评价轻度PSP患者的灰质和白色改变。14名轻度PSP患者和14名健康对照者进入研究，并根据标准化评估进行临床和神经心理学评估。每例受试者均接受了结构磁共振成像（MRI）研究。MRI数据进行处理分析，根据优化的VBM和分数各向异性determined.Results：与对照组相比，在PSP患者的VBM分析显示了一个显着的集群减少运动前皮质，额盖，前额叶，海马，海马旁回，双侧灰质。关于皮质下脑区，丘脑的枕，背内侧和前核，以及上级和下层丘受到影响的双边。双侧减少分数各向异性在上级纵束，胼胝体，弓状束，丘脑后辐射，和内囊，可能涉及皮质-延髓束，是目前在PSP patients.Conclusions：这些数据提供了证据，从早期疾病阶段的灰色和白色物质变性的PSP。这些结构变化表明，皮质和皮质下结构的萎缩和特定纤维束的神经变性有助于PSP的神经功能缺损。
Background: A comprehensive characterisation of grey and white matter changes in progressive supranuclear palsy ( PSP), the second most common extrapyramidal syndrome after Parkinson disease, is still not available.Objective: To evaluate grey and white matter changes in mild PSP patients by voxel based morphometry ( VBM) and diffusion tensor imaging ( DTI), respectively.Methods: 14 mild PSP patients and 14 healthy controls entered the study and underwent a clinical and neuropsychological evaluation according with a standardised assessment. Each subject had a structural magnetic resonance imaging ( MRI) study. Processing analysis of MRI data was carried out according to optimised VBM and fractional anisotropy was determined.Results: Compared with the controls, in PSP patients VBM analysis showed a significant clusters of reduced grey matter in premotor cortex, frontal operculum, anterior insula, hippocampus, and parahippocampal gyrus, bilaterally. With regard to subcortical brain regions, the pulvinar, dorsomedial and anterior nuclei of the thalamus, and superior and inferior culliculum were affected bilaterally. A bilateral decrease in fractional anisotropy in superior longitudinal fasciculus, anterior part of corpus callosum, arcuate fascicolus, posterior thalamic radiations, and internal capsule, probably involving the cortico- bulbar tracts, was present in PSP patients.Conclusions: These data provide evidence for both grey and white matter degeneration in PSP from the early disease stage. These structural changes suggest that atrophy of cortical and subcortical structures and neurodegeneration of specific fibre tracts contribute to neurological deficits in PSP.