Function of Deptor and its roles in hematological malignancies.
Function of Deptor and its roles in hematological malignancies.
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DOI：
10.18632/aging.202462
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发表时间：
2021-01-07
期刊：
影响因子：
--
通讯作者：
Vega MI
中科院分区：
文献类型：
--
作者：
Morales-Martinez M;Lichtenstein A;Vega MI
Deptor是一种与mTOR相互作用的蛋白质，属于mTORC1和mTORC2复合体。Deptor能抑制mTOR的激酶活性。众所周知，mTOR通路参与多种信号通路，这些信号通路参与细胞生长、细胞凋亡、自噬和内质网应激反应等多种生物学过程。因此，Deptor作为mTOR的天然抑制剂，在其研究中变得非常重要。因此，研究其在人类恶性肿瘤尤其是血液系统恶性肿瘤发生发展中的作用具有重要意义。由于Deptor在癌症中表达的多样性，人们认为Deptor可以作为癌基因或肿瘤抑制因子，这取决于细胞或组织背景。本文就其转录和转录后调控Deptor的研究进展作一综述。以及Deptor在血液系统恶性肿瘤中的活性，其作为生物标志物的可能作用，以及在这些恶性肿瘤中可能的临床意义的研究进展。
Deptor is a protein that interacts with mTOR and that belongs to the mTORC1 and mTORC2 complexes. Deptor is capable of inhibiting the kinase activity of mTOR. It is well known that the mTOR pathway is involved in various signaling pathways that are involved with various biological processes such as cell growth, apoptosis, autophagy, and the ER stress response. Therefore, Deptor, being a natural inhibitor of mTOR, has become very important in its study. Because of this, it is important to research its role regarding the development and progression of human malignancies, especially in hematologic malignancies. Due to its variation in expression in cancer, it has been suggested that Deptor can act as an oncogene or tumor suppressor depending on the cellular or tissue context. This review discusses recent advances in its transcriptional and post-transcriptional regulation of Deptor. As well as the advances regarding the activities of Deptor in hematological malignancies, its possible role as a biomarker, and its possible clinical relevance in these malignancies.
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