The different surrogate measures of adiposity in relation to semen quality and serum reproductive hormone levels among Estonian fertile men
The different surrogate measures of adiposity in relation to semen quality and serum reproductive hormone levels among Estonian fertile men
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DOI：
10.1111/andr.12002
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发表时间：
2015-03-01
期刊：
影响因子：
4.5
通讯作者：
Punab, M.
中科院分区：
文献类型：
--
作者：
Ehala-Aleksejev, K.;Punab, M.
本研究的目的是探讨不同肥胖替代指标：体重指数(BMI)、体脂百分比(BF%)、腰围(WC)和腰高比(WHtR)与精液基本参数和生殖激素的关系。爱沙尼亚一所大学医院男科中心对260名孕妇的男性伴侣进行了标准精液分析和血清生殖激素水平测定。四分位分析显示，所有肥胖标记物与性激素结合球蛋白和总睾酮水平呈负相关。调整协变量后，高BF%、WC和WHtR与精子总数呈负相关。BF%与精液量呈负相关。这些显著变化发生在BF%23.4%，WC&>98 cm和WHtR&>；0.54。除了这些变化，BMI与精子参数无关。这项研究表明，中心性肥胖会影响精液质量，并证实了早先的发现，即肥胖会显著改变血清性激素水平。需要进一步的研究来找出什么是最好的身体成分标记物，最清楚地显示肥胖、精液特征和性激素水平之间的关系。
The objective of this study was to investigate the relations of basic semen parameters and reproductive hormones with different surrogate measures of adiposity: body mass index (BMI), body fat percentage (BF%), waist circumference (WC) and waist-to-height ratio (WHtR). Standard semen analysis was performed and serum levels of reproductive hormones were measured in 260 male partners of pregnant women at a university hospital andrology centres in Estonia. Quartile analysis revealed that all adiposity markers were negatively related to sex hormone-binding globulin and total testosterone levels. After adjustment for covariates a high BF%, WC and WHtR were negatively associated with total sperm count. The BF% was also negatively related to semen volume. These significant changes occurred from a BF%23.4%, WC>98cm and WHtR>0.54. Next to these changes the BMI was not related to sperm parameters. This study shows that semen quality is affected by central adiposity and confirms earlier findings that adiposity markedly changes serum sex hormone levels. Further studies are required to find out what is the best body composition marker showing most clearly the relationships between adiposity, semen characteristics and sex hormone levels.