Calcineurin: a poorly understood regulator of muscle mass.
Calcineurin: a poorly understood regulator of muscle mass.
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DOI：
10.1016/j.biocel.2013.06.029
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发表时间：
2013-10
影响因子：
4
通讯作者：
Price, S. Russ
中科院分区：
文献类型：
--
作者：
Hudson, Matthew B.;Price, S. Russ
本综述将讨论现有文献，这些文献研究了钙调神经磷酸酶 (CnA) 在与肥大性生长或萎缩相关的情况下调节骨骼肌质量的作用。肌肉质量由蛋白质合成和降解之间的平衡决定，而蛋白质合成和降解之间的平衡由许多细胞内信号通路控制，最显着的是胰岛素/IGF/磷脂酰肌醇 3-激酶 (PI3K)/Akt 系统。尽管钙调磷酸酶 (CnA) 被 IGF-1 激活，并且在确定肌纤维表型方面具有明确的功能，但钙调神经磷酸酶 (CnA)（一种 Ca2+ 激活的丝氨酸/苏氨酸磷酸酶）及其下游信号传导伴侣作为肌肉质量的调节剂却很少受到关注。与其他信号通路相比，检查 CnA 在肌肉大小调节中的作用的研究相对较少，但得出的结果不一致。这些差异的原因并不明显，但可能是由于所研究的遗传模型的选择性、各种肌肉中 CnA 活性内源水平的波动以及 CnA 抑制剂抑制 CnA 信号传导的不同用途。尽管结果不一致，但有足够的直接和间接证据表明 CnA 在骨骼肌质量的调节中发挥作用。
This review will discuss the existing literature that has examined the role of calcineurin (CnA) in the regulation of skeletal muscle mass in conditions associated with hypertrophic growth or atrophy. Muscle mass is determined by the balance between protein synthesis and degradation which is controlled by a number of intracellular signaling pathways, most notably the insulin/IGF/phosphatidylinositol 3-kinase (PI3K)/Akt system. Despite being activated by IGF-1 and having well-described functions in the determination of muscle fiber phenotypes, calcineurin (CnA), a Ca2+-activated serine/threonine phosphatase, and its downstream signaling partners have garnered little attention as a regulator of muscle mass. Compared to other signaling pathways, the relatively few studies that have examined the role of CnA in the regulation of muscle size have produced discordant results. The reasons for these differences is not obvious but may be due to the selective nature of the genetic models studied, fluctuations in the endogenous level of CnA activity in various muscles, and the variable use of CnA inhibitors to inhibit CnA signaling. Despite the inconsistent nature of the outcomes, there is sufficient direct and indirect evidence to conclude that CnA plays a role in the regulation of skeletal muscle mass.
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DOI：
10.1083/jcb.153.2.329
发表时间：
2001-04-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Horsley V;Friday BB;Matteson S;Kegley KM;Gephart J;Pavlath GK
通讯作者：
Pavlath GK
影响因子：
4.1
作者：
Chhabra, Ravindresh;Dubey, Richa;Saini, Neeru
通讯作者：
Saini, Neeru
影响因子：
4.8
作者：
Lecker, SH;Jagoe, RT;Goldberg, AL
通讯作者：
Goldberg, AL
DOI：
10.1097/01.mco.0000165005.01331.45
发表时间：
2005-05-01
影响因子：
3.1
作者：
Franch, HA;Price, SR
通讯作者：
Price, SR
影响因子：
5.5
作者：
Allen, David L.;Loh, Amanda S.
通讯作者：
Loh, Amanda S.