Cortical topography of human anterior intraparietal cortex active during visually guided grasping
Cortical topography of human anterior intraparietal cortex active during visually guided grasping
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DOI：
10.1016/j.cogbrainres.2004.11.010
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发表时间：
2005-05-01
期刊：
影响因子：
--
通讯作者：
Grafton, ST
中科院分区：
文献类型：
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作者：
Frey, SH;Vinton, D;Grafton, ST
灵巧的手动伸缩需要成功地转换物体的内在空间属性的感觉表示（例如，形状）成用于配置手的相对空间的运动计划。在猕猴中，这些感觉运动转换是在连接前顶内沟（AIP区）和下额叶皮层（F5ab区）的回路中完成的。视觉引导抓握过程中人类前顶内沟（aIPS）的激活表明猕猴区AIR的同源物。如果是真的，那么尽管皮质地形图存在个体差异，视觉引导抓握应始终与IPS和中央后沟交界处的局灶性激活相关。功能磁共振成像被用来测试这一假设在14个右撇子adultes.Despite实质性的变化，在IPS地形，对比钳抓与达到复杂的不对称形状显示激活病灶的IPS和中央后回的交界处在所有14个人。该部位可能位于Brodmann 40区的最上级吻侧，对应于von Economo和Koskinas定义的PF或PDE区以及沃格特及其同事定义的86区。在人类和猕猴中，这一区域似乎在视觉引导抓取中起着关键作用。(c)2004 Elsevier B.V.保留所有权利。
Dexterous manual prehension requires successfully transforming sensory representations of an object's intrinsic spatial properties (e.g., shape) into motor plans for configuring the opposition space of the hand. In macaques, these sensorimotor transformations are accomplished in a circuit connecting the anterior intraparietal sulcus (area AIP) with inferior frontal cortex (area F5ab). Activation in the human anterior intraparietal sulcus (aIPS) during visually guided grasping suggests a homologue of macaque area AIR If true, then despite individual variation in cortical topography, visually guided grasping should be consistently associated with focal activation at the junction of the IPS and postcentral sulcus. FMRI was used to test this hypothesis in 14 right-handed adults.Despite substantial variability in IPS topography, a contrast between pincer grasping vs. reaching to complex asymmetrical shapes revealed activation foci at the junction of the IPS and postcentral gyrus in all 14 individuals. This site is likely within the most superior, rostral aspect of Brodmann's area 40, corresponding to area PF or PDE as defined by von Economo and Koskinas, and area 86 as defined by Vogt and colleagues. In both humans and macaques this region appears to play a key role in visually guided grasping. (c) 2004 Elsevier B.V. All rights reserved.