Estimating dioxin-like polychlorinated biphenyl toxic equivalents from total polychlorinated biphenyl measurements in fish
Estimating dioxin-like polychlorinated biphenyl toxic equivalents from total polychlorinated biphenyl measurements in fish
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DOI：
10.1897/06-621r.1
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发表时间：
2007-08-01
影响因子：
4.1
通讯作者：
Jackson, Donald A.
中科院分区：
文献类型：
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作者：
Bhavsar, Satyendra P.;Hayton, Alan;Jackson, Donald A.
多氯联苯(PCB)是209种相关化合物，其中十几种被称为二恶英样多氯联苯(dl-PCbs)，是毒性最大的多氯联苯之一。多氯联苯对人类健康造成许多不利影响，包括癌症，是北美鱼类警告的主要原因。人们普遍认为，需要量化个别多氯联苯化合物，特别是dl-多氯联苯，而不是总多氯联苯，以预测环境危害，因为它们的毒性潜力和在包括水生食物网在内的各种环境基质中的分布存在差异。由于目前用于定量dl-pcbs的分析方法很复杂，而且价格要贵四到五倍，因此需要对有限的鱼类样本进行dl-pcbs的分析。使用可能是最大的dl-多氯联苯鱼类数据集(n=912)，其中广泛分布了鱼类种类(n=22)、大小(19-112厘米)、重量(100-14,300克)、性别(男性，51：49)和多氯联苯污染水平(20-7,300 ng/g湿重量)；我们表明，相对便宜和快速的鱼类多氯联苯总量测量可用于评估与dl-多氯联苯相关的毒理学危害，以2，3，7，8-四氯二苯并对二恶英毒性当量(TEQ)衡量。给出了鱼体内与多氯联苯相关的总环境质量(即总环境质量(dl-多氯联苯))与总多氯联苯的回归方程(总多氯联苯(dl-多氯联苯)=[2.56X10(-5)]C-总多氯联苯，r=0.89，p<；0.001)。通过将其应用于三个大小相当的独立数据集(n=55、141和176)来评估回归。使用回归和总的多氯联苯测量估计的TEQ(dl-多氯联苯)在根据dl-多氯联苯测量计算的二三个TEQ(dl-多氯联苯)的合理系数内。评价的成功表明了回归的通用性。
Polychlorinated biphenyls (PCBs) are 209 related compounds, a dozen of which are known as dioxin-like PCBs (dl-PCBs) and are among the most toxic PCBs. Polychlorinated biphenyls contribute to many adverse effects to human health, including cancer, and are a major cause of fish advisories in North America. It is a common perception that individual PCB compounds, especially dl-PCBs, rather than total PCB need to be quantified to predict the environmental hazard because of differences in their toxicity potential and distribution among various environmental matrices, including aquatic food webs. Because the current analytical methods for quantifying dl-PCBs are complex and four- to fivefold more expensive, limited fish samples are analyzed for dl-PCBs. Using what likely is the largest dl-PCB fish data set (n = 912) with a wide distribution of fish species (n = 22), size (19-112 cm), weight (100-14,300 g), sex (malefemale, 51:49), and PCB contamination level (20-7,300 ng/g wet wt); we show that the comparatively less expensive and rapid measurements of total PCB in fish can be utilized to assess dl-PCB-related toxicological hazard, measured as 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalents (TEQ). A regression equation of dl-PCB-related TEQ (i.e., TEQ(dl-PCB)) to total PCB in fish is presented (TEQ(dl-PCB) = [2.56 X 10(-5)]C-total PCB, r = 0.89, p < 0.001). The regression was evaluated by applying it to three independent data sets of substantial sizes (n = 55, 141, and 176). The TEQ(dl-PCB) estimated using the regression and total PCB measurements were within a reasonable factor of two to three of the TEQ(dl-PCB) calculated from the dl-PCB measurements. The successful evaluation indicates versatility of the regression.