Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes
Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes
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DOI：
10.1097/mco.0b013e32833aab7f
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发表时间：
2010-07-01
影响因子：
3.1
通讯作者：
Eckel, Juergen
中科院分区：
文献类型：
--
作者：
Sell, Henrike;Eckel, Juergen
综述目的肥胖与脂肪组织中的低级别慢性炎症有关。本文综述了人类和啮齿动物对脂肪渗透免疫细胞的性质、脂肪组织渗透的时间过程和潜在机制的研究进展。最近对啮齿动物的深入研究表明，不仅天然免疫系统的细胞进入脂肪组织，而且各种适应性免疫的淋巴细胞也参与了脂肪的炎症过程。几项研究还提供了肥胖症开始时巨噬细胞和淋巴细胞出现的顺序。脂肪细胞和前脂肪细胞通过分泌趋化脂肪因子也是积极的参与者。综述综述了强有力的证据表明，在啮齿动物肥胖和代谢的背景下，脂肪组织中的先天和获得性免疫系统的作用之间存在联系，但需要在人类中进行更多的研究，以将这一主题与人类生理学联系起来。在肥胖的不同阶段针对不同的免疫细胞可能最终导致代谢综合征的新治疗方法。
Purpose of reviewObesity is associated with low-grade chronic inflammation in adipose tissue. This review presents an update on human and rodent studies analyzing the nature of fat-infiltrating immune cells, the time course of adipose tissue infiltration and underlying mechanisms.Recent findingsIntensive studies in rodents have shown that not only cells of the innate immune system traffic into adipose tissue but also various lymphocytes of the adaptive immunity are involved in inflammatory processes in fat. Several studies also provide insight in the order of appearance of macrophages and lymphocytes during the onset of obesity. Adipocytes and preadipocytes are also active players by their secretion of chemotactic adipokines.SummaryThis review summarizes strong evidence for a link between the action of innate and adaptive immune systems in adipose tissue in the context of obesity and metabolism in rodents, but more studies in humans are necessary to relate this topic to human physiology. Targeting different immune cells at different stages of obesity may eventually lead to novel therapeutic approaches for the metabolic syndrome.