Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages
Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages
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DOI：
10.1002/jcp.28518
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发表时间：
2019-10-01
影响因子：
5.6
通讯作者：
Du, Xianjin
中科院分区：
文献类型：
--
作者：
Hu, Xiaorong;Cai, Xinyong;Du, Xianjin
动脉粥样硬化仍然是全世界发病和死亡的主要原因。最近，据报道组织铁水平升高会增加动脉粥样硬化的风险。然而，铁诱导动脉粥样硬化进展的详细机制却鲜为人知。在这里，我们使用 apoE 缺陷小鼠模型来研究低铁饮食的影响（
Atherosclerosis is still the major cause of morbidity and mortality all over the world. Recently, it has been reported increased levels of tissue iron increase the risk of atherosclerosis. However, the detailed mechanism of iron-induced atherosclerosis progression is barely known. Here, we used apoE-deficient mice models to investigate the effects of low iron diet (