Pharmacologic approaches to daytime and nighttime symptoms of allergic rhinitis
Pharmacologic approaches to daytime and nighttime symptoms of allergic rhinitis
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DOI：
10.1016/j.jaci.2004.08.045
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发表时间：
2004-01-01
影响因子：
14.2
通讯作者：
Storms, William W.
中科院分区：
文献类型：
--
作者：
Storms, William W.
过敏性鼻炎与睡眠障碍、白天嗜睡和疲劳有关。鼻炎与睡眠障碍之间的确切关系尚不清楚；然而，过敏性鼻炎的症状和潜在病理都会影响睡眠质量。鼻塞已被证明会导致睡眠呼吸障碍，被认为是鼻炎相关睡眠障碍的主要原因。鼻塞的严重程度遵循昼夜节律，在夜间和清晨最严重。时间疗法是研究给药时间对药物治疗安全性和有效性的影响，基于药物的药代动力学和药效学的昼夜节律影响。变应性鼻炎的时间疗法研究表明，夜间服用抗过敏药物是有益的。例如，抗组胺药mequitazine在晚上给药比早晨给药效果更好。需要更多的研究来确定这是否是一种阶级效应。白三烯受体拮抗剂适用于晚间给药；这些药物显著改善夜间鼻炎症状。在早晨使用鼻内皮质类固醇已证明对改善夜间症状有效；然而，晚上bbb是否能改善夜间鼻炎症状尚不清楚。由于夜间鼻炎症状对生活质量有显著的不利影响，应评估变应性鼻炎治疗在改善夜间症状方面的疗效。[J]中华过敏症杂志，2004;16(3):368 - 368。
Allergic rhinitis is associated with sleep disturbances, daytime somnolence, and fatigue. The exact relationship between rhinitis and sleep disturbance is unknown; however, both the symptoms and underlying pathology of allergic rhinitis can interfere with sleep quality. Nasal congestion, which has been shown to cause sleep-disordered breathing, is thought to be primarily responsible for rhinitis-related sleep disorders. The severity of nasal congestion follows a circadian rhythm, being worst at night and in the early morning. Chronotherapy is the study of the effects of administration time on the safety and efficacy of drug therapy based on circadian influences on the pharmacokinetics and pharmacodynamics of medications. Chronotherapy studies in allergic rhinitis suggest there are benefits to nighttime dosing of antiallergy medications. For example, the antihistamine mequitazine has shown improved efficacy when administered in the evening compared with morning dosing. More study is needed to determine whether this is a class effect. Leukotriene receptor antagonists are indicated for evening administration; these drugs significantly improve nighttime rhinitis symptoms. Intranasal corticosteroids administered in the morning have demonstrated efficacy in improving nighttime symptoms; however, it is unknown whether evening administration would improve their effects on nocturnal rhinitis symptoms. Because of the significant detrimental effects of nocturnal rhinitis symptoms on quality of life, allergic rhinitis therapies should be evaluated for efficacy in ameliorating nighttime symptoms. (J Allergy Clin Immunol 2004; 114: S146-53.)