Chromane isolated from leaves of Dillenia indica improves the neuronal dysfunction in STZ-induced diabetic neuropathy
Chromane isolated from leaves of Dillenia indica improves the neuronal dysfunction in STZ-induced diabetic neuropathy
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DOI：
10.1016/j.jep.2017.05.018
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发表时间：
2017-07-12
影响因子：
5.4
通讯作者：
Singh, Randhir
中科院分区：
文献类型：
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作者：
Kaur, Navpreet;Kishore, Lalit;Singh, Randhir
民族药理学相关性：根据印度传统医学，Dillenia indica L. 对多种疾病显示出治疗功效。该植物的果实和叶子具有抗氧化和抗炎特性。活性氧、晚期糖基化终末产物 (AGE) 的形成和细胞凋亡与糖尿病神经病变的发病机制有关。本研究的目的：本研究的目的是探讨 D. indica 及其分离物色满 (CR) 对链脲佐菌素诱导的实验性糖尿病中热和机械痛觉过敏、异常性疼痛、MNCV 和氧化亚硝化应激的影响。材料和方法：糖尿病是由腹膜内给予链脲佐菌素（STZ；65 mg/kg）以治疗糖尿病神经病变。从 STZ 给药第 60 天开始，用 DAE（100、200 和 400 mg/kg，口服）和 CR（5 和 10 mg/kg，口服）长期治疗 30 天。明显的痛觉过敏和异常性疼痛明显表明神经病的发展；减少与 AGE 和活性氧形成增加相关的 MNCV。结果：显着减弱与糖尿病神经病变相关的行为和生化变化。目前的研究表明，DAE 和 CR 通过调节糖尿病大鼠的氧化亚硝化应激和减少 AGEs 形成来改善高血糖和糖尿病神经性疼痛。结论：因此，D. indica 可能对慢性糖尿病患者有益，改善糖尿病神经病变的进展，也可能在糖尿病神经性疼痛中得到应用。
Ethnopharmacological relevance: According to the Indian traditional medicine, Dillenia indica L. has shown therapeutic efficacy in various diseases. Fruits and leaves of the plant possess anti-oxidant and anti-inflammatory properties. Reactive oxygen species, formation of advanced glycation end products (AGEs) and apoptosis are implicated in the pathogenesis of diabetic neuropathy.Aim of the study: The aim of the present study was to explore the effect of D. indica and its isolate, chromane (CR), on thermal and mechanical hyperalgesia, allodynia, MNCV and oxidative-nitrosative stress in streptozotocin-induced experimental diabetes.Material and methods: Diabetes was induced by intraperitoneal administration of Streptozotocin (STZ; 65 mg/kg) for the development of diabetic neuropathy. Chronic treatment with DAE (100, 200 and 400 mg/kg, p.o.) and CR (5 and 10 mg/kg, p.o.) for 30 days was started from the 60th day of STZ administration. Development of neuropathy was evident from a marked hyperalgesia and allodynia; reduced MNCV associated with increased formation of AGEs and reactive oxygen species.Results: significantly attenuated behavioral and biochemical changes associated with diabetic neuropathy. Present study suggested that DAE and CR ameliorated hyperglycemia and diabetic neuropathic pain via modulation of oxidative-nitrosative stress and reduction in AGEs formation in the diabetic rats.Conclusion: Thus D. indica might be beneficial in chronic diabetics, ameliorate the progression of diabetic neuropathy and may also find application in diabetic neuropathic pain.