Vegetable and fruit consumption and the risk of hormone receptor-defined breast cancer in the EPIC cohort
Vegetable and fruit consumption and the risk of hormone receptor-defined breast cancer in the EPIC cohort
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DOI：
10.3945/ajcn.114.101436
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发表时间：
2016-01-01
影响因子：
7.1
通讯作者：
van Gils, Carla H.
中科院分区：
文献类型：
--
作者：
Emaus, Marleen J.;Peeters, Petra H. M.;van Gils, Carla H.
背景资料：最近的文献表明，高蔬菜摄入量，而不是高水果摄入量可能与降低类固醇激素受体阴性乳腺癌的风险。目的：本研究旨在调查蔬菜和水果摄入量与类固醇激素受体定义的乳腺癌风险之间的关联。设计：欧洲癌症与营养前瞻性研究（EPIC）队列中共有335，054名女性参与者纳入本研究（平均值+/- SD年龄：50.8 +/- 9.8岁）。蔬菜和水果的摄入量是通过1992年至2000年招募时填写的针对具体国家的问卷来测量的，使用的是标准化程序。考克斯比例风险模型分层年龄在招聘和研究中心，并调整乳腺癌的危险factors.Results：经过中位数随访11.5年（IQR：10.1-12.3年），10,197例浸润性乳腺癌被诊断[3479雌激素和孕激素受体阳性（ER+PR+），1021 ER和PR阴性（ER-PR-）]。与最低的五分位数相比，蔬菜摄入量最高的五分位数与总体乳腺癌风险较低相关（HRquintile（5-quintile）（1）：0.87; 95%CI：0.80，0.94）。尽管ER-PR-乳腺癌的负相关性最明显，（ER-PR-：HR五分位数5-五分位数1：0.74; 95% CI：0.57，0.96; P-趋势= 0.03; ER+PR+：HR五分位数5-五分位数1：0.91; 95% CI：0.79，1.05; P趋势= 0.14），激素受体状态的异质性检验不显著（P异质性= 0.09）。水果摄入量与总的和激素受体定义的乳腺癌risk.Conclusion：这项研究支持的证据表明，高蔬菜摄入量与较低（主要是激素受体阴性）乳腺癌的风险。
Background: The recent literature indicates that a high vegetable intake and not a high fruit intake could be associated with decreased steroid hormone receptor-negative breast cancer risk.Objective: This study aimed to investigate the association between vegetable and fruit intake and steroid hormone receptor-defined breast cancer risk.Design: A total of 335,054 female participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were included in this study (mean +/- SD age: 50.8 +/- 9.8 y). Vegetable and fruit intake was measured by country-specific questionnaires filled out at recruitment between 1992 and 2000 with the use of standardized procedures. Cox proportional hazards models were stratified by age at recruitment and study center and were adjusted for breast cancer risk factors.Results: After a median follow-up of 11.5 y (IQR: 10.1-12.3 y), 10,197 incident invasive breast cancers were diagnosed [3479 estrogen and progesterone receptor positive (ER+PR+); 1021 ER and PR negative (ER-PR-)]. Compared with the lowest quintile, the highest quintile of vegetable intake was associated with a lower risk of overall breast cancer (HRquintile (5-quintile) (1): 0.87; 95% CI: 0.80, 0.94). Although the inverse association was most apparent for ER-PR- breast cancer (ER-PR- : HRquintile 5-quintile 1: 0.74; 95% CI: 0.57, 0.96; P-trend = 0.03; ER+PR+: HRquintile 5-quintile 1: 0.91; 95% CI: 0.79, 1.05; P-trend = 0.14), the test for heterogeneity by hormone receptor status was not significant (P-heterogeneity = 0.09). Fruit intake was not significantly associated with total and hormone receptor-defined breast cancer risk.Conclusion: This study supports evidence that a high vegetable intake is associated with lower (mainly hormone receptor-negative) breast cancer risk.