Parenteral interferon-alpha treatment of psoriasis.
Parenteral interferon-alpha treatment of psoriasis.
复制标题
胃肠外干扰素-α治疗牛皮癣。
DOI：
10.1159/000248777
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
E. Aberer
中科院分区：
文献类型：
--
作者：
R. Neumann;H. Pohl;E. Aberer
12例银屑病患者接受重组干扰素（IFN）-α-2c，每日剂量为2.5 × 10（6）或5 × 10（6）IU，通过肌肉注射途径给药长达4周。1例患者在12个月随访后显示完全消退，并且保持无病变。3例患者被判定为部分缓解，鳞屑形成停止，皮肤病变变平。8例患者未观察到有益效果。由于IFN-α应用的副作用，如发热、头痛、不适和寒战在随后的治疗中消失。我们的研究结果表明IFN-α在银屑病中可能具有积极作用。
12 patients suffering from psoriasis were given recombinant interferon (IFN)-alpha-2c at a daily dosage of 2.5 X 10(6) or 5 X 10(6) IU for up to 4 weeks by the intramuscular route. One patient showed complete regression and remained free of lesions after 12 months of follow-up. Three patients were judged as partial remission with stop of scale formation and flattening of skin lesions. No beneficial effect was seen in 8 patients. Side effects due to IFN-alpha application, such as fever, headache, malaise, and chills disappeared with subsequent treatments. Our findings suggest a possible positive effect of IFN-alpha in psoriasis.