Adamantane-resistant influenza a viruses in the world (1902-2013): frequency and distribution of M2 gene mutations.
Adamantane-resistant influenza a viruses in the world (1902-2013): frequency and distribution of M2 gene mutations.
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DOI：
10.1371/journal.pone.0119115
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
He H
中科院分区：
文献类型：
--
作者：
Dong G;Peng C;Luo J;Wang C;Han L;Wu B;Ji G;He H
金刚烷（金刚烷胺和金刚乙胺）已被用于预防和治疗甲型流感病毒感染多年;然而，对这些药物的耐药性已在世界上广泛报道。为了研究1902年至2013年期间在世界范围内流行的金刚烷耐药流感病毒变异体中M2基因突变的频率和分布，分析了来自不同HA亚型甲型流感病毒（H1-H17）的31251个可用M2蛋白序列，并比较了金刚烷耐药相关突变（L26 F、V27 A、A30 T、A30 V、S31 N、G34 E和L38 F）。我们发现，全球流行的甲型流感（H1-H17）病毒中有45.2%（n = 14132）对金刚烷具有耐药性，绝大多数耐药病毒（95%）携带S31 N突变。然而，只有约1%的人有V27 A突变，其他突变（L26 F，A30 T，G34 E和L38 F）非常罕见（其患病率似乎< 0.2%）。我们的结果证实，H1、H3、H5、H7、H9和H17亚型甲型流感病毒对金刚烷表现出高水平的耐药性。相反，金刚烷抗性突变体在H2、H4、H6、H10和H11亚型中的出现是罕见的。然而，在其他HA亚型（H8、H12-H16）中未鉴定出金刚烷抗性病毒。我们的研究结果表明，金刚烷耐药流感病毒变异体的频率和分布在不同的HA亚型，宿主物种，隔离年数和地理区域之间存在差异。这项全面的研究引起了人们对金刚烷耐药甲型流感病毒日益流行的担忧，并强调了监测金刚烷耐药变异体的出现和全球传播的重要性。
Adamantanes (amantadine and rimantadine) have been used to prevent and treat influenza A virus infections for many years; however, resistance to these drugs has been widely reported in the world. To investigate the frequency and distribution of M2 gene mutations in adamantane-resistant influenza variants circulated in the world between 1902 and 2013, 31251 available M2 protein sequences from different HA-subtype influenza A viruses (H1–H17) were analyzed and adamantane resistance-associated mutations were compared (L26F, V27A, A30T, A30V, S31N, G34E, and L38F). We find that 45.2% (n = 14132) of influenza A (H1–H17) viruses circulating globally were resistant to adamantanes, and the vast majority of resistant viruses (95%) bear S31N mutations. Whereas, only about 1% have V27A mutations and other mutations (L26F, A30T, G34E, and L38F) were extremely rare (their prevalence appeared to be < 0.2%). Our results confirm that H1, H3, H5, H7, H9, and H17 subtype influenza A viruses exhibit high-level resistance to adamantanes. In contrast, the appearance of adamantane-resistant mutants in H2, H4, H6, H10, and H11 subtypes was rare. However, no adamantane resistance viruses were identified among other HA subtypes (H8, H12–H16). Our findings indicate that the frequency and distribution of adamantane-resistant influenza variants varied among different HA subtypes, host species, years of isolation, and geographical areas. This comprehensive study raises concerns about the increasing prevalence of adamantane-resistant influenza A viruses and highlights the importance of monitoring the emergence and worldwide spread of adamantane-resistant variants.
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影响因子：
6.4
作者：
BELSHE, RB;BURK, B;SIM, IS
通讯作者：
SIM, IS
影响因子：
6.4
作者：
Deyde, Varough M.;Xu, Xiyan;Klimov, Alexander I.
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Klimov, Alexander I.
DOI：
10.1053/spid.2002.122999
发表时间：
2002-04-01
期刊：
Seminars in pediatric infectious diseases
影响因子：
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Englund, Janet A
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Barr, I. G.;Hurt, A. C.;Komadina, N.
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Komadina, N.