Congenital malformations associated with anencephaly in liveborn and stillborn infants.
Congenital malformations associated with anencephaly in liveborn and stillborn infants.
复制标题
与活产和死产婴儿无脑畸形相关的先天畸形。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
P. Baird
中科院分区：
文献类型：
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作者：
A. Sadovnick;P. Baird
从人口为基础的不列颠哥伦比亚省健康监测登记处的记录进行了检查，并确定了456名婴儿无脑畸形（181例活产儿，275例死胎）。登记记录列出了每个个体最多4例先天性畸形，并对研究队列的记录进行了审查，以确定是否存在其他畸形。除无脑儿外，共有12.7%的婴儿（14.4%的活产婴儿，11.6%的死胎婴儿）患有先天性畸形。特定先天性畸形的频率（例如，无脑儿畸形婴儿的畸形（包括畸形足、唇腭裂、脐膨出）发生率与肝脏的一般人群中这些畸形的发生率进行比较。此外，与死胎相比，活产无脑儿中其他先天性畸形的类型也进行了研究。这种相似性表明，不仅仅是这些额外的先天性畸形的存在导致了子宫内死亡。这些数据为神经管缺陷的病因异质性提供了进一步的证据。
Records from the population-based British Columbia Health Surveillance Registry were examined, and a total of 456 infants with anencephaly (181 liveborns, 275 stillborns) were identified. Registry records list up to four congenital malformations per individual, and the records of the study cohort were reviewed for the presence of additional malformations. A total of 12.7% of infants (14.4% liveborns, 11.6% stillborns) had congenital malformations in addition to anencephaly. The frequencies of specific congenital malformations (e.g., talipes, cleft lip and/or palate, omphalocele) in infants with anencephaly were compared with the frequencies of these malformations in the general population of liveborns. In addition, the types of additional congenital malformations in liveborn anencephalics compared to stillborns were looked at. The similarity suggests that it is not just the presence of these additional congenital malformations that leads to death in utero. The data provide further evidence for etiological heterogeneity in neural tube defects.