Isolation and characterization of polybrominated diphenyl ethers as inhibitors of microtubule assembly from the marine sponge Phyllospongia dendyi collected at Palau
Isolation and characterization of polybrominated diphenyl ethers as inhibitors of microtubule assembly from the marine sponge Phyllospongia dendyi collected at Palau
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DOI：
10.1021/np0304621
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发表时间：
2004-03-01
影响因子：
5.1
通讯作者：
Yao, XS
中科院分区：
文献类型：
--
作者：
Liu, HW;Namikoshi, M;Yao, XS
采用生物测定法从帕劳海绵体中分离出2个新的多溴联苯醚（1和2）和9个已知化合物（3-11）。这些结构是根据它们的光谱数据分配的。化合物3、7和10对微管蛋白组装（IC50分别为29.6、33.5和20.9 muM）和海星卵母细胞减数分裂成熟（IC50分别为3.6、4.2和4.2 muM）有抑制作用，而1、2、4-6、8、9和11在100 muM时无抑制作用。它们的生物活性需要两个酚羟基。
Two new polybrominated diphenyl ethers (1 and 2) were isolated by bioassay-guided separations together with nine known compounds (3-11) from the marine sponge Phyllospongia dendyi collected from Palau. The structures were assigned on the basis of their spectral data. Compounds 3, 7, and 10 showed inhibitory activities to the assembly of microtubule proteins (IC50: 29.6, 33.5, and 20.9 muM, respectively) and to the meiotic maturation of starfish oocytes (IC50: 3.6, 4.2, and 4.2 muM, respectively), while 1, 2, 4-6, 8, 9, and 11 were not active at 100 muM. Two phenolic hydroxyls are required for their bioactivities.