CD33-related siglecs as potential modulators of inflammatory responses
CD33-related siglecs as potential modulators of inflammatory responses
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DOI：
10.1111/j.1749-6632.2011.06449.x
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Richards, Hannah E.
中科院分区：
文献类型：
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作者：
Crocker, Paul R.;McMillan, Sarah J.;Richards, Hannah E.
免疫系统必须严格调节，以防止由过度的免疫和炎症反应引起的不必要的组织损伤。抑制性和激活性免疫受体通过磷酸酪氨酸依赖性信号传导途径在此功能中发挥关键作用。大量的证据表明唾液酸结合Ig样凝集素的siglec家族对这种免疫调节做出了重要贡献。CD33相关的单克隆细胞是抑制性和激活性受体的不同子集，主要以细胞类型特异性方式在白细胞上表达。在这里，我们严格评估在体外和体内的证据CD33相关的单细胞在炎症和免疫反应的调制的功能作用。
The immune system must be tightly regulated to prevent unwanted tissue damage caused by exaggerated immune and inflammatory reactions. Inhibitory and activating immune receptors play a crucial role in this function via phosphotyrosine-dependent signaling pathways. A significant body of evidence has accumulated suggesting that the siglec family of sialic acid binding Ig-like lectins makes an important contribution to this immunoregulation. The CD33-related siglecs are a distinct subset of inhibitory and activating receptors, expressed primarily on leukocytes in a cell type-specific manner. Here, we critically assess the in vitro and in vivo evidence on the functional role for CD33-related siglecs in modulation of inflammatory and immune responses.