Parvalbumin is constantly expressed in chromophobe renal carcinoma
Parvalbumin is constantly expressed in chromophobe renal carcinoma
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DOI：
10.1038/modpathol.3880386
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发表时间：
2001-08-01
期刊：
影响因子：
7.5
通讯作者：
Bonetti, F
中科院分区：
文献类型：
--
作者：
Martignoni, G;Pea, M;Bonetti, F
肾嫌色细胞癌是由肿瘤细胞组成，其特征与集合管闰细胞相似。由于远端肾单位表达钙结合蛋白，在钙稳态中发挥作用，我们推断这些蛋白可以由嫌色细胞癌表达，因此代表诊断标志物。我们研究了不同的钙结合蛋白（小清蛋白，钙结合蛋白-D28 K，钙视网膜蛋白）在140个肾肿瘤，包括75个传统的（透明细胞）癌，32嫌色细胞癌，17乳头状肾细胞癌，16嗜酸细胞瘤的免疫组化表达。小清蛋白在所有原发性嫌色细胞癌和胰腺转移瘤中均呈强阳性;在16例嗜酸细胞瘤中有11例呈阳性，而在常规（透明细胞）和乳头状肾细胞癌（原发性或转移性）中不存在。钙结合蛋白-D28 K和钙视网膜蛋白在所有肿瘤中均为阴性，除了两个嫌色细胞癌，四个嗜酸细胞瘤和两个乳头状肾细胞癌显示不明显的钙视网膜蛋白表达。我们的数据表明，小清蛋白可能是一个合适的标志物区分原发性和转移性嫌色细胞癌从传统的（透明细胞）和乳头状肾细胞癌。此外，他们提出了嫌色肾癌和肾嗜酸细胞瘤之间的关系，并表明嫌色癌表现出向集合管表型分化。
Chromophobe renal carcinoma is composed of neoplastic cell showing several features similar to those found in the intercalated cells of the collecting ducts. Because the distal nephron expresses calcium-binding proteins playing a role in calcium homeostasis, we reasoned that these proteins could be expressed by chromophobe carcinoma and therefore represent a diagnostic marker. We studied the immunohistochemical expression of different calcium-binding proteins (parvalbumin, calbindin-D28K, and calretinin) in 140 renal tumors, including 75 conventional (clear cell) carcinomas, 32 chromophobe carcinomas, 17 papillary renal cell carcinomas, and 16 oncocytomas. Parvalbumin was strongly positive in all primary chromophobe carcinomas and in one pancreatic metastasis; it was positive in 11 of 16 oncocytomas and absent in conventional (clear cell) and papillary renal cell carcinomas, either primary or metastatic. Calbindin-D28K and calretinin were negative in all tumors, with the exception of two chromophobe carcinomas, four oncocytomas, and two papillary renal cell carcinomas showing inconspicuous calretinin expression. Our data demonstrate that parvalbumin may be a suitable marker for distinguishing primary and metastatic chromophobe carcinoma from conventional (clear cell) and papillary renal cell carcinoma. Moreover, they suggest a relationship between chromophobe renal carcinoma and renal oncocytoma and indicate that chromophobe carcinoma exhibits differentiation toward the collecting-duct phenotype.