Single-cell RNA-seq reveals the links between the metabolic heterogeneity and cell identity in NBM and AML.
Single-cell RNA-seq reveals the links between the metabolic heterogeneity and cell identity in NBM and AML.
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DOI：
10.1111/bjh.19233
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发表时间：
2023-11
影响因子：
6.5
通讯作者：
Qiongyu Lu;Wenqiang Qu;Yuxin Wen;Peng Ke;Luyao Zhao;Qingyuan Wang;Suning Chen;Z. Zeng
中科院分区：
文献类型：
--
作者：
Qiongyu Lu;Wenqiang Qu;Yuxin Wen;Peng Ke;Luyao Zhao;Qingyuan Wang;Suning Chen;Z. Zeng
本文探讨了急性髓细胞白血病（AML）在单细胞水平的代谢异质性。该研究表明，AML细胞表现出独特的代谢特征，代谢异质性与细胞分化和某些遗传改变相关。研究人员还发现，正常骨髓和AML中的原始细胞类型显示出更高的代谢异质性。这些发现强调了了解代谢异质性对于识别耐药细胞亚型和改善AML治疗干预的重要性。英国血液学杂志的版权是Wiley-Blackwell的财产，未经版权保持器的明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印，下载或电子邮件的文章供个人使用。这篇摘要可以删节。不保证副本的准确性。用户应参考原始出版版本的材料的完整摘要。版权适用于所有摘要。
This article explores the metabolic heterogeneity of acute myeloid leukemia (AML) at the single-cell level. The study reveals that AML cells exhibit distinct metabolic features and that metabolic heterogeneity is correlated with cell differentiation and certain genetic alterations. The researchers also found that primitive cell types in both normal bone marrow and AML display higher metabolic heterogeneity. The findings highlight the importance of understanding metabolic heterogeneity for identifying drug-resistant subtypes of cells and improving therapeutic interventions for AML.[Extracted from the article]Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.