Incidence of stroke and its association with glycemic control and lifestyle in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry
Incidence of stroke and its association with glycemic control and lifestyle in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry
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DOI：
10.1016/j.diabres.2020.108518
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发表时间：
2021-03-04
影响因子：
5.1
通讯作者：
Kitazono, Takanari
中科院分区：
文献类型：
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作者：
Iwase, Masanori;Komorita, Yuji;Kitazono, Takanari
目的：我们前瞻性地调查了日本2型糖尿病患者中风及其亚型，危险因素和预后的发病率：共4,875名参与者与2型糖尿病（平均年龄65.4岁，男性57%，以前中风10%）进行了调查，中风的发展为5年。使用多变量调整后的考克斯比例models.Results：发病率每1,000人年为6.7新发卒中（缺血性5.5，出血性1.2）和22.7复发性卒中（缺血性18.8，出血性3.8），分别。缺血性卒中与年龄、男性、减少规律体力活动、HbA 1c、糖尿病肾病和既往卒中显著相关。腔隙性脑梗死与肥胖、定期体力活动减少、HbA（1c）和糖尿病肾病显著相关，而动脉粥样硬化血栓性卒中与年龄、膳食纤维摄入减少、定期体力活动减少、HbA（1c）和既往卒中显著相关。复发性脑卒中与抑郁症状显著相关。出血性卒中的30天和1年生存率分别为76%和64%，缺血性卒中分别为96%和91%.Conclusions：目前的研究再次强调了血糖控制和生活方式改变的重要性，如定期体育锻炼预防2型糖尿病患者卒中。(C)2020 Elsevier B. V.保留所有权利。
Aims: We prospectively investigated the incidence of stroke and its subtypes, risk factors and prognosis in Japanese patients with type 2 diabetes.Methods: A total of 4,875 participants with type 2 diabetes (mean age 65.4 years, male 57%, previous stroke 10%) were investigated for the development of stroke for 5 years. Risk factors were evaluated using multivariable adjusted Cox proportional models.Results: The incidence rates per 1,000 person-years were 6.7 for new-onset stroke (ischemic 5.5, hemorrhagic 1.2) and 22.7 for recurrent stroke (ischemic 18.8, hemorrhagic 3.8), respectively. Ischemic stroke was significantly associated with age, male, reduced regular physical activity, HbA(1c), diabetic kidney disease and previous stroke. Lacunar infarction was significantly associated with obesity, reduced regular physical activity, HbA(1c) and diabetic kidney disease, whereas atherothrombotic stroke was significantly associated with age, reduced intake of dietary fiber, reduced regular physical activity, HbA(1c) and previous stroke. Recurrent stroke was significantly associated with depressive symptom. Thirty-day and one-year survival was 76% and 64% for hemorrhagic stroke, and 96% and 91% for ischemic stroke, respectively.Conclusions: The current study reemphasized the importance of glycemic control and life-style modification such as regular physical exercise for stroke prevention in patients with type 2 diabetes. (C) 2020 Elsevier B.V. All rights reserved.