Dual Functional Peptide-Driven Nanoparticles for Highly Efficient Glioma-Targeting and Drug Codelivery
Dual Functional Peptide-Driven Nanoparticles for Highly Efficient Glioma-Targeting and Drug Codelivery
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DOI：
10.1021/acs.molpharmaceut.6b00051
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发表时间：
2016-05-01
影响因子：
4.9
通讯作者：
Jiang, Chen
中科院分区：
文献类型：
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作者：
Kuang, Yuyang;Jiang, Xutao;Jiang, Chen
与周围性肿瘤相比，胶质瘤的治疗非常困难，不仅因为它具有肿瘤的一般特征，而且由于治疗受到脑血屏障（BBB）的限制。肿瘤生长的两个主要特征是血管生成和肿瘤细胞的增殖。RNA干扰（RNAi）可下调VEGF过表达，抑制肿瘤新生血管形成。同时，多柔比星（DOX）已被用于细胞毒性化疗，以杀死肿瘤细胞。因此，RNAi联合化疗被认为是一种潜在的癌症治疗策略。然而，血脑屏障限制了shVEGF-DOX共递送系统直接进入胶质瘤。本研究建立了一种双功能肽修饰的智能给药系统，该系统可以靶向血脑屏障和胶质瘤上过表达的转铁蛋白受体（TfR）。结果表明，该双靶向给药系统在体内体外均具有较高的肿瘤靶向效率。
Compared with peripheral tumors, glioma is very difficult to treat, not only because it has general features of tumor but also because the therapy has been restricted by the brain-blood barrier (BBB). The two main features of tumor growth are angiogenesis and proliferation of tumor cells. RNA interference (RNAi) can downregulate VEGF overexpression to inhibit tumor neovascularization. Meanwhile, doxorubicin (DOX) has been used for cytotoxic chemotherapy to kill tumor cells. Thus, combining RNAi and chemotherapy has been regarded as a potential strategy for cancer treatment. However, the BBB limits the shVEGF-DOX codelivery system to direct into glioma. Here, a smart drug delivery system modified with a dual functional peptide was established, which could target to transferrin receptor (TfR) overexpressing on both the BBB and glioma. It showed that the dual-targeting delivery system had high tumor targeting efficiency in vitro and in vivo.