Plasma pteridine concentrations in patients with chronic renal failure
Plasma pteridine concentrations in patients with chronic renal failure
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DOI：
10.1093/ndt/17.6.1032
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发表时间：
2002-06-01
影响因子：
6.1
通讯作者：
Hosoya, T
中科院分区：
文献类型：
--
作者：
Yokoyama, K;Tajima, M;Hosoya, T
背景。尿毒症状态下蝶啶代谢受损。这可能会影响心血管功能并导致营养不良。我们希望进一步阐明蝶啶代谢受损的影响。方法。使用 HPLC 方法，测定了 64 名慢性肾功能衰竭患者（33 名接受间歇性血液透析 (HD) 治疗，31 名尚未接受肾脏替代治疗）和 18 名健康对照者的内源性蝶啶血浆浓度。根据肌酐清除率（Ccr）将患者分为三组：（a）组，Ccr>60ml/min； (b)组，Ccr=10-60ml/min； (c)组，所有患者接受HD。结果。 (c)组(118.9+/-11.7 ng/ml， 18.8+/-1.2 ng/ml、6.79+/-0.53 和 0.26+/-0.06）比健康受试者（5.17+/-0.29 ng/ml、2.83+/-0.19 ng/ml、1.92+/-0.13 和 1.15+/-0.11；P
Background. Pteridine metabolism is impaired in the uraemic state. This may affect cardiovascular function and contribute to malnutrition. We wished to clarify further the impact of impaired pteridine metabolism.Methods. Using the HPLC method, the plasma concentrations of endogenous pteridines were determined in 64 patients with chronic renal failure (33 on intermittent haemodialysis (HD) treatment vs 31 not yet on renal replacement therapy), and in 18 healthy controls. The patients were classified into three groups on the basis of creatinine clearance (Ccr): group (a), Ccr >60 ml/min; group (b), Ccr=10-60 ml/min; group (c), all patients receiving HD.Results. Total neopterin (NP) and biopterin (BP) levels and the NP/BP ratio (a biomarker for macrophage activity) were significantly higher, whereas tetrahydrobiopterin (BH4)/dihydrobiopterin (BH2) ratio (a biomarker for nitric oxide synthase and phenylalanine hydroxylase activities) was significantly lower in, group (c) (118.9+/-11.7 ng/ml, 18.8+/-1.2 ng/ml, 6.79+/-0.53, and 0.26+/-0.06) than in healthy subjects (5.17+/-0.29 ng/ml, 2.83+/-0.19 ng/ml, 1.92+/-0.13, and 1.15+/-0.11; P