Association between overall rate of change in rising breath alcohol concentration and the magnitude of acute tolerance of subjective intoxication via the Mellanby method.
Association between overall rate of change in rising breath alcohol concentration and the magnitude of acute tolerance of subjective intoxication via the Mellanby method.
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DOI：
10.1002/hup.2565
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
McCarthy DM
中科院分区：
文献类型：
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作者：
Morris DH;Amlung MT;Tsai CL;McCarthy DM
急性耐受性的大小是长期慢性耐受性发展的强有力预测因素，并在风险决策中起决定性作用（例如，酒后驾车）。因此，重要的是要确定增加这种适应过程的幅度的因素。本研究探讨了急性耐受量是否随呼气酒精浓度（BrAC）总体增加率的变化而变化。29名年轻成年社交饮酒者（M年龄= 22.55，SD = 3.10; 62.1%女性）在受控实验室环境中摄入中等剂量的酒精（男性：0.86 g/kg，女性：0.75 g/kg）。在匹配的BrAC（~0.060 g/dL）下评估BrAC曲线各分支的主观中毒。分层回归结果表明，上升肢体BrAC的整体增加速度更快，与主观中毒评级的急性耐受性更高相关（p <0.01，R2 = 0.29）。这些结果提供了一些初步证据，表明BrAC的快速增加可能与更大的急性耐受性相关，如BrAC曲线各分支的主观中毒程度降低所示。这种更大的减少反过来可能会促进更重的饮酒和/或参与不适合的行为（例如，酒后驾车）。
The magnitude of acute tolerance is a strong predictor of the development of longer term, chronic tolerance and plays a decisive role in risky decisions (e.g., driving after drinking). Therefore, it is important to identify factors that increase the magnitude of this adaptive process. The present study explored whether acute tolerance magnitude varied as a function of the overall rate of increase in breath alcohol concentration (BrAC). Twenty-nine young adult social drinkers (M age = 22.55, SD = 3.10; 62.1% female) consumed a moderate dose of alcohol (men: 0.86 g/kg, women: 0.75 g/kg) in a controlled laboratory setting. Subjective intoxication was assessed at matched BrACs (~0.060 g/dL) on each limb of the BrAC curve. Hierarchical regression results indicated that faster overall increases in BrAC on the ascending limb were associated with greater acute tolerance for subjective intoxication ratings (p < .01, R2 = .29). These results present some of the first evidence that faster increases in BrAC may be associated with greater acute tolerance, as indicated by greater reduction in subjective intoxication across the limbs of the BrAC curve. This greater reduction may, in turn, promote heavier drinking and/or engagement in behaviors for which one is unfit (e.g., driving after drinking).