Is oxytocin receptor signaling really dispensable for social attachment?
Is oxytocin receptor signaling really dispensable for social attachment?
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DOI：
10.1016/j.cpnec.2023.100178
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发表时间：
2023-05
影响因子：
--
通讯作者：
Connelly, Jessica J.
中科院分区：
文献类型：
--
作者：
Danoff, Joshua S.;Whelan, Emma A.;Connelly, Jessica J.
我们认为没有足够的证据支持Berendzen等人的主要结论，特别是催产素受体在基因上并不需要成对结合。首先，他们还没有创造出一个真正的“敲除”来阻止Oxtr的完全转录能力。他们的两个突变等位基因仍然可以产生一些潜在的功能转录本，包括含有第一个完整跨膜结构域的蛋白质的一部分，这是一个潜在的功能单元，已被证明在其他系统中调节GPCR活性[21]。其次，没有生化或药理学证据表明催产素信号确实被消除了，这将减轻第一个担忧。最后，缺乏行为表型是令人担忧的。我们承认有许多基因参与了这种复杂的行为，并且OXTR可能不是配对结合的主要驱动因素。即便如此，通过这里描述的基因操作产生的动物不仅继续表现出草原田鼠[22]中典型的成对结合的选择性社会行为，而且还具有养育后代的能力。虽然没有具体描述这需要泌乳，但许多研究表明，这一功能需要一种功能性的催产素受体（见其他地方）。我们赞赏Berendzen等人为该领域的未来工作提供了Oxtr突变体，但我们敦促这些作者通过仔细彻底的实验来跟进他们的工作，为他们的主张提供确凿的证据。
We believe there is insufficient evidence for the main conclusion made by Berendzen et al. specifically that oxytocin receptor is not genetically required for a pair bond. First, they have not created a true“knockout” that prevents the full transcriptional ability of Oxtr. Two of their mutant alleles could still make a number of potentially functional transcripts, including a portion of the protein containing the first full transmembrane domain, a potentially functional unit which has been shown to modulate GPCR activity in other systems [21]. Second, there was no biochemical or pharmacological evidence indicating that oxytocin signaling was truly abolished, which would alleviate the first concern. Finally, the lack of a behavioral phenotype is worrisome. We acknowledge that there are many genes involved in this complex behavior and that it is possible that OXTR may not be a major driver of pair bonding. Even so, the animals produced by the genetic manipulations described here continued to not only show selective social behaviors that characterize pair bonding in prairie voles [22], but also have the capacity to rear offspring. Although not specifically described this would require milk ejection, a function shown in many studies to necessitate a functional oxytocin receptor (reviewed elsewhere [20]). We applaud Berendzen et al. for providing the field with Oxtr mutants for future work, but we urge these authors to follow up their work with careful and thorough experiments that provide conclusive evidence for their claims.
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影响因子：
5.5
作者：
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通讯作者：
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作者：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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