Clostridium difficile ribotype 027 is most prevalent among inpatients admitted from long-term care facilities
Clostridium difficile ribotype 027 is most prevalent among inpatients admitted from long-term care facilities
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DOI：
10.1016/j.jhin.2014.06.016
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发表时间：
2014-12-01
影响因子：
6.9
通讯作者：
Guerrant, R. L.
中科院分区：
文献类型：
--
作者：
Archbald-Pannone, L. R.;Boone, J. H.;Guerrant, R. L.
使用粪便乳铁蛋白和核糖分型对 196 名患有艰难梭菌感染的住院成人进行肠道炎症评估，以确定核糖分型 027 对长期护理机构 (LTCF) 的影响。 LTCF 居民 (n = 28) 的抗生素使用量较多 (P = 0.049)，核糖型 027 感染较多 [比值比 (OR)：4.87； 95%置信区间（CI）：2.02-11.74； P < 0.01]，与从家里入院的患者相比。与感染非 027 菌株的患者相比，感染核糖型 027 菌株的患者六个月死亡率更差（OR：1.90；95% CI：1.08-3.34；P = 0.03），炎症程度更高（95.26 vs 36.08 mg/mL；P = 0.006）。这项研究的目的不是确定感染地点，但在该人群中，表明患者入院的地点与核糖型 027 和更严重的艰难梭菌疾病密切相关。 (C) 2014 年医疗保健感染协会。由爱思唯尔有限公司出版。保留所有权利。
Intestinal inflammation was evaluated using faecal lactoferrin and ribotype in 196 hospitalized adults with Clostridium difficile infection to determine the impact of ribotype 027 in long-term care facilities (LTCFs). LTCF residents (n = 28) had greater antibiotic use (P = 0.049) and more ribotype 027 infection [odds ratio (OR): 4.87; 95% confidence interval (CI): 2.02-11.74; P < 0.01], compared to those admitted from home. Patients infected with ribotype 027 strains had worse six-month mortality (OR: 1.90; 95% CI: 1.08-3.34; P = 0.03) and more inflammation (95.26 vs 36.08 mg/mL; P = 0.006), compared to those infected with non-027 strains. This study was not designed to determine acquisition site, but, in this population, suggests that the location from which the patient has been admitted is strongly associated with ribotype 027 and more severe C. difficile disease. (C) 2014 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.