A STUDY OF SUPERSENSITIVITY IN DENERVATED MAMMALIAN SKELETAL MUSCLE
A STUDY OF SUPERSENSITIVITY IN DENERVATED MAMMALIAN SKELETAL MUSCLE
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DOI：
10.1113/jphysiol.1959.sp006233
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发表时间：
1959-01-01
影响因子：
5.5
通讯作者：
THESLEFF, S
中科院分区：
文献类型：
--
作者：
AXELSSON, J;THESLEFF, S
用离子导入法研究了慢性失神经哺乳动物骨骼肌对乙酰胆碱（ACh）的敏感性。在神经支配的肌肉中，ACh仅在施加到肌纤维的终板区域时产生膜去极化，并且对ACh敏感的区域仅占据肌膜的非常有限的部分。在去神经支配的肌肉中，整个膜变得对ACh敏感，并且无论ACh施加在膜上何处，它都会产生与施加到神经支配的肌肉的终板区域时类似的幅度和时间过程的去极化。ACh对膜Na和K渗透性的影响在失神经肌肉中与在正常终板中相同。在失神经肌肉中使用抗胆碱酯酶剂不会增强ACh的作用。虽然失神经肌肉的整个膜对ACh敏感，但肌纤维仍然是电兴奋的。
The sensitivity to acetyl-choline (ACh) of chronically denervated mammalian skeletal muscle was studied by iontophoretic application of the agent to single muscle fibers while membrane potentials were simultaneously recorded. In an innervated muscle, ACh produces membrane depolarization only when applied to the end-plate region of the muscle fiber and the area sensitive to ACh occupies only a very limited part of the muscle membrane. In a denervated muscle the entire membrane becomes sensitive to ACh and wherever it is applied on the membrane it produces a depolarization of similar magnitude and time course as when applied to the end-plate area of an innervated muscle. The effect of ACh on membrane permeability to Na and K is the same in denervated muscle as at the normal end-plate. The use of anticholinesterases in denervated muscle does not potentiate the effects of ACh. Although the whole membrane in a denervated muscle is sensitive to ACh, the muscle fibers remain electrically excitable.