NC-1900, an arginine-vasopressin analogue, ameliorates social behavior deficits and hyperlocomotion in MK-801-treated rats: Therapeutic implications for schizophrenia
NC-1900, an arginine-vasopressin analogue, ameliorates social behavior deficits and hyperlocomotion in MK-801-treated rats: Therapeutic implications for schizophrenia
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DOI：
10.1016/j.brainres.2005.06.035
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发表时间：
2005-08-16
期刊：
影响因子：
2.9
通讯作者：
Kurachi, M
中科院分区：
文献类型：
--
作者：
Matsuoka, T;Sumiyoshi, T;Kurachi, M
我们以前报道过，长期给予N-甲基-D-天冬氨酸（NMDA）拮抗剂降低了大鼠几个脑区的血管加压素Via受体的密度，这些脑区表现出社会互动缺陷和运动活动增加。这些观察结果表明，精氨酸加压素（AVP）或其类似物能够调节与NMDA受体阻滞相关的行为异常。本研究旨在探讨AVP类似物NC-1900对非竞争性NMDA受体拮抗剂MK-801处理的大鼠社会行为和自发活动的影响。雄性Wistar大鼠接受MK-801（0.13 mg/kg/天ip）或生理盐水给药14天。在NC-1900（10 ng/kg sc）或生理盐水以及末次MK-801或溶媒给药后45 min，测量社交行为和自发活动。通过自动视频跟踪系统量化社会互动，并手动测量刻板行为和共济失调。NC-1900的急性给药部分逆转了MK-801诱导的过度运动和社会互动缺陷，而NC-1900本身并不影响用溶剂盐水长期给药的动物的这些行为指标。这些结果表明，中枢AVP系统可能与多巴胺能和多巴胺能的传输相互作用，并表明AVP类似物对精神分裂症的阳性和阴性症状的潜在治疗作用。(c)2005 Elsevier B. V.保留所有权利。
We previously reported that chronic administration of N-methyl-D-aspartate (NMDA) antagonists reduced the density of vasopressin Via receptors in several brain regions in rats that demonstrated social interaction deficits and increased locomotor activity. These observations indicate the ability of arginine-vasopressin (AVP), or its analogues, to modulate behavioral abnormalities associated with blockade of NMDA receptors.-The present study was performed to investigate the effect of NC-1900, an AVP analogue, on social behavior and locomotor activity in rats treated with MK-801, a non-competitive NMDA receptor antagonist. Male Wistar rats were administered MK-801 (0.13 mg/kg/day ip) or saline for 14 days. Social behavior and locomotor activity were measured 45 min after the injection of NC-1900 (10 ng/kg sc) or saline together with the last MK-801 or vehicle administration. Social interaction was quantified by an automated video-tracking system, and stereotyped behavior and ataxia were manually measured. Acute administration of NC-1900 partially reversed MK-801-induced hyperlocomotion and deficits in social interaction, while NC-1900 itself did not affect these behavioral measures in animals chronically treated with vehicle saline. These results suggest that the central AVP system may interact with glutamatergic and dopaminergic transmissions, and indicate potential therapeutic effects of AVP analogues on positive and negative symptoms of schizophrenia. (c) 2005 Elsevier B.V. All rights reserved.