Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
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DOI：
10.1101/gad.12.20.3252
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发表时间：
1998-10-15
影响因子：
10.5
通讯作者：
Perrimon, N
中科院分区：
文献类型：
--
作者：
Harrison, DA;McCoon, PE;Perrimon, N
在脊椎动物中，许多细胞因子和生长因子已被确定为JAK/STAT信号通路的激活剂。在果蝇中，TAK和STAT分子已经被分离出来，但没有描述能够激活该途径的配体或受体。我们已经描述了未配对（upd）基因，它显示出与果蝇TAK （hopscotch）和STAT （stat92E）基因突变相同的独特的胚胎突变缺陷。Upd是一种分泌蛋白，与细胞外基质相关，可激活TAK通路。我们提出Upd是一种依赖TAK信号的配体，在早期果蝇胚胎中以节段限制的方式刺激成对规则基因的转录。
In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, TAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila TAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the TAK pathway. We propose that Upd is a ligand that relies on TAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo.