Association between fetal sex and pregnancy outcomes among women with twin pregnancies: a multicenter cross-sectional study
Association between fetal sex and pregnancy outcomes among women with twin pregnancies: a multicenter cross-sectional study
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DOI：
10.1007/s00404-022-06623-z
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发表时间：
2022-05-27
影响因子：
2.6
通讯作者：
Sago，Haruhiko
中科院分区：
文献类型：
--
作者：
Funaki，Satoru;Ogawa，Kohei;Sago，Haruhiko
PurposeTo检查的频率和胎儿性别在多大程度上与双胎妊娠的妊娠结局，分层chorionicity.MethodsThis注册为基础的多中心横断面研究是使用日本妇产科学会围产期数据库在2007年和2016年之间进行。样本人群仅限于双胎妊娠的妇女。主要妊娠相关结局包括早产、极早产、极早产、先兆子痫、双胎输血综合征（TTTS）和选择性宫内生长受限（s-IUGR）。出生体重，小于胎龄儿（SGA），和胎儿死亡也investigated.ResultsThe主要分析进行了基于37,953名妇女，其中包括23,804名妇女与绒毛膜双羊膜腔（DD）双胞胎和14,149名妇女与单绒毛膜双羊膜腔（MD）双胞胎。与女性/女性DD双胞胎相比，男性/男性DD双胞胎女性的早产风险显著更高（校正风险比[aRR]：1.07，95%置信区间[CI]：1.03-1.10），先兆子痫风险较低（aRR：0.74，95% CI：0.62-0.88）。男性/男性MD双胞胎的妇女也有显着较高的早产风险（aRR：1.06，95% CI：1.04-1.09）比女性/女性MD双胞胎的妇女。MD妊娠中先兆子痫、TTTS和s-IUGR的风险在性别上没有差异。男性SGA的风险显着高于男性/男性双胞胎比男性/女性DD双胞胎。在MD双胞胎中，SGA和胎儿死亡的风险显着较高的男性/男性fetus.ConclusionsThis研究表明，胎儿性别和几个妊娠结局在双胞胎妊娠，其中一些不同的绒毛膜。
PurposeTo examine the frequency and to what extent fetal sex is associated with pregnancy outcomes among twin pregnancies, stratified by chorionicity.MethodsThis registry-based multicenter cross-sectional study was conducted using the Japan Society of Obstetrics and Gynecology perinatal database between 2007 and 2016. The sample population was restricted to women with twin pregnancies. The main pregnancy-related outcomes included preterm birth, very preterm birth, extremely preterm birth, preeclampsia, twin-to-twin transfusion syndrome (TTTS), and selective intrauterine growth restriction (s-IUGR). Birth weight, small for gestational age (SGA), and fetal death were also investigated.ResultsThe primary analysis was performed based on 37,953 women, including 23,804 women with dichorionic diamniotic (DD) twins and 14,149 women with monochorionic diamniotic (MD) twins. Women with male/male DD twins had a significantly higher risk of preterm birth (adjusted risk ratio [aRR]: 1.07, 95% confidence interval [CI]: 1.03–1.10) and a lower risk of preeclampsia (aRR: 0.74, 95% CI: 0.62–0.88) than women with female/female DD twins. Women with male/male MD twins also had a significantly higher risk of preterm birth (aRR: 1.06, 95% CI: 1.04–1.09) than women with female/female MD twins. Risks of preeclampsia, TTTS, and s-IUGR did not differ by sex among MD pregnancies. Male SGA risk was significantly higher among male/male twins than among male/female DD twins. Among MD twins, risks of SGA and fetal death were significantly higher in male/male fetuses.ConclusionsThis study demonstrated significant associations between fetal sex and several pregnancy outcomes in twin pregnancies, some of which differed by chorionicity.