ASYMPTOMATIC CARRIAGE OF NEISSERIA-MENINGITIDIS IN A RANDOMLY SAMPLED POPULATION
ASYMPTOMATIC CARRIAGE OF NEISSERIA-MENINGITIDIS IN A RANDOMLY SAMPLED POPULATION
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DOI：
10.1128/jcm.32.2.323-330.1994
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发表时间：
1994-02-01
影响因子：
9.4
通讯作者：
FROHOLM, LO
中科院分区：
文献类型：
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作者：
CAUGANT, DA;HOIBY, EA;FROHOLM, LO
为了估计挪威人口中脑膜炎双球菌携带者的程度，并调查人口的几个特征与携带者状态的关系，从挪威国家人口登记处随机抽取了1,500名居住在奥斯陆附近农村和小城镇地区的人。这些人被要求完成一份调查问卷，并自愿进行扁桃体咽拭子细菌学采样。63%的被选人参与了调查。91名志愿者(9.6%)携带脑膜炎奈瑟菌。对分离的菌株进行血清型、分型、抗生素耐药性测试，并进行多位点酶电泳法分析。在91个分离株中，有8个(8.8%)代表两个克隆复合体的克隆，这两个克隆复合体是导致20世纪80年代挪威大多数系统性脑膜炎球菌病的原因。Logistic回归分析发现，年龄在15-24岁之间、男性、主动和被动吸烟与脑膜炎球菌携带率独立相关。在对性别和吸烟进行更正后，外出工作、从事运输或工业也会增加17岁以上的人携带脑膜炎双球菌的风险。假设我们的样本代表挪威人口，我们估计挪威约有4万人是具有流行潜力的分离株的无症状携带者。因此，在系统性疾病患者的密切接触者中根除携带者不太可能对总体流行病学情况产生重大影响。
To estimate the extent of meningococcal carriage in the Norwegian population and to investigate the relationship of several characteristics of the population to the carrier state, 1,500 individuals living in rural and small-town areas near Oslo were selected at random from the Norwegian National Population Registry. These persons were asked to complete a questionnaire and to volunteer for a bacteriological tonsillopharyngeal swab sampling. Sixty-three percent of the selected persons participated in the survey. Ninety-one (9.6%) of the volunteers harbored Neisseria meningitidis. The isolates were serogrouped, serotyped, tested for antibiotic resistance, and analyzed by multilocus enzyme electrophoresis. Eight (8.8%) of the 91 isolates represented clones of the two clone complexes that have been responsible for most of the systemic meningococcal disease in Norway in the 1980s. Age between 15 and 24, male sex, and active and passive smoking were found to be independently associated with meningococcal carriage in logistic regression analyses. Working outside the home and having an occupation in transportation or industry also increased the risk for meningococcal carriage in individuals older than 17, when corrections for gender and smoking were made. Assuming that our sample is representative of the Norwegian population,, we estimated that about 40,000 individuals in Norway are asymptomatic carriers of isolates with epidemic potential. Thus, carriage eradication among close contacts of persons with systemic disease is unlikely to have a significant impact on the overall epidemiological situation.