Determination of the prognostic value of [18F]fluorodeoxyglucose uptake by using positron emission tomography in patients with non-small cell lung cancer
Determination of the prognostic value of [18F]fluorodeoxyglucose uptake by using positron emission tomography in patients with non-small cell lung cancer
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DOI：
10.1097/00006231-200209000-00010
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发表时间：
2002-09-01
影响因子：
1.5
通讯作者：
Shim, YS
中科院分区：
文献类型：
--
作者：
Jeong, HJ;Min, JJ;Shim, YS
本研究的目的是确定从[F-18]氟脱氧葡萄糖正电子发射断层扫描（F-18-FDG PET）获得的定量信息是否对非小细胞肺癌（NSCLC）患者具有预后意义。我们研究了73例NSCLC患者的F-18-FDG PET显像。不同组织病理类型（鳞癌37例（12.4 ± 5.1），腺癌30例（8.2 ± 5.8），细支气管肺泡癌4例（2.6 ± 1.7），P < 0.01）的最大标准化摄取值（SUVmax）有显著性差异。在所有患者的单变量分析中，分期（P=0.0001）、肿瘤细胞类型（P=0.013）和SUVmax大于7（P=0.0011）与生存相关。然而，多变量分析表明，分期和SUVmax大于7对生存率有不利影响。I组疾病（I期至IIIA期）患者的死亡率比II组疾病（IIIB期至IV期）患者低5.8倍。高SUVmax（≥7）患者的死亡率是低SUVmax（< 7）患者的6.3倍。通过对鳞状细胞癌患者的多因素分析，只有分组影响生存率（P = 0.008，相对危险度= 4.3）。在腺癌病例中，SUVmax（>10）仅与较差的生存率相关（P=0.031，相对危险度= 11.152）。F-18-FDG摄取与NSCLC生存率相关。特别是在腺癌中，SUVmax与其他已知的预后因素互补。((C)2002 Lippincott威廉姆斯威尔金斯）。
The aim of this study was to determine whether quantitative information obtained from [F-18]fluorodeoxyglucose positron emission tomography (F-18-FDG PET) has a prognostic significance for patients with non-small cell lung cancer (NSCLC). We investigated F-18-FDG PET imaging of 73 patients with NSCLC. The maximum standardized uptake value (SUVmax) was significantly different between the histopathological types of tumour (squamous cell carcinoma (n=37, 12.4+/-5.1), adenocarcinoma (n=30, 8.2+/-5.8), bronchioloalveolar carcinoma (n = 4, 2.6 +/- 1.7), P < 0.01). In the univariate analysis of all patients, staging (P=0.0001), tumour cell type (P=0.013), and a SUVmax greater than 7 (P=0.0011) was correlated with survival. However, a multivariate analysis identified staging and SUVmax greater than 7 were affected survival adversely. The mortality rate of patients with group I disease (stage I to stage IIIA) was 5.8 times lower than that of patients with group II disease (stage IIIB to stage IV). Patients with a high SUVmax (≥7) had a 6.3 times higher mortality than those with a low SUVmax, (< 7). By multivariate analysis of patients with squamous cell carcinoma, only grouping affected survival (P = 0.008, relative risk = 4.3). In the case of adenocarcinoma, the SUVmax (>10) correlated exclusively with poorer survival (P=0.031, relative risk = 11.152). F-18-FDG uptake correlated with survival in NSCLC. Especially in adenocarcinomas, the SUVmax was complementary to other known prognostic factors. ((C) 2002 Lippincott Williams Wilkins).