Socially dominant mice in C57BL6 background show increased social motivation
Socially dominant mice in C57BL6 background show increased social motivation
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DOI：
10.1016/j.bbr.2017.08.038
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发表时间：
2018-01-15
影响因子：
2.7
通讯作者：
Wang, Hongbing
中科院分区：
文献类型：
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作者：
Kunkel, Thaddeus;Wang, Hongbing
在成年雄性C57BL6小鼠身上进行了一系列行为测试，以衡量社交优势、社交动机和非社交动机。通过使用著名的管优势检验来确定社会优势和等级，我们发现，在没有竞争资源和交配的情况下，群养小鼠笼友表现出稳定的、大多是线性的和传递的社会等级关系。社会地位最高和最低的老鼠要接受三室社交互动测试，以衡量社交动机。排名靠前的老鼠比排名靠后的老鼠花更多的时间与陌生人互动，这表明社交优势可能会对社交动机产生积极影响。当处于一个新的环境中时，不同社会等级的小鼠在旷场测试中表现出相似的移动和探索活动，这表明在非社会动机的某些方面没有明显的差异。这些结果表明，社会支配地位和社会动机之间存在行为相关性。
A series of behavioral tests measuring social dominance, social motivation, and non-social motivation are examined in adult male C57BL6 mice. By using the well-known tube dominance test to determine social dominance and rank, we find that, in the absence of competition for resource and mating, group-housed mouse cage-mates display stable and mostly linear and transitive social hierarchies. Mice with top and bottom social ranks are subjected to a three-chamber social interaction test to measure social motivation. The top ranked mice spend more time interacting with a stranger mouse than the bottom ranked mice, suggesting that social dominance may positively influence social motivation. When subjected to a novel environment, mice with different social ranks show similar locomotion and exploring activity in the open field test, suggesting no detectable difference in certain aspects of non-social motivation. These results demonstrate a behavioral correlation between social dominance and social motivation.