Total Synthesis of (-)-Huperzine A
Total Synthesis of (-)-Huperzine A
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DOI：
10.1021/ol9022408
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发表时间：
2009-11-19
期刊：
影响因子：
5.2
通讯作者：
Fukuyama, Tohru
中科院分区：
文献类型：
--
作者：
Koshiba, Takahiro;Yokoshima, Satoshi;Fukuyama, Tohru
(-)-石杉碱甲的全合成由市售酸酐经过 23 个步骤完成。我们的合成路线的特点是可以轻松构建双环[3.3.1]骨架，并配备适当的功能来引入剩余的子结构。
The total synthesis of (-)-huperzine A was accomplished in 23 steps from a commercially available anhydride. Our synthetic route features a facile construction of the bicyclo[3.3.1] skeleton equipped with proper functionalities to introduce the remaining substructures.