Multifunctional Core-Shell-Corona-Type Polymeric Micelles for Anticancer Drug-Delivery and Imaging
Multifunctional Core-Shell-Corona-Type Polymeric Micelles for Anticancer Drug-Delivery and Imaging
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DOI：
10.1002/chem.201203958
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发表时间：
2013-04-01
影响因子：
4.3
通讯作者：
Yamauchi, Yusuke
中科院分区：
文献类型：
--
作者：
Bastakoti, Bishnu Prasad;Wu, Kevin C. -W.;Yamauchi, Yusuke
We have developed core-shell-corona-type polymeric micelles that can integrate multiple functions in one system, including the capability of accommodating hydrophobic dyes into core and hydrophilic drug into the shell, as well as pH-triggered drug-release. The neutral and hydrophilic corona sterically stabilizes the multifunctional polymeric micelles in aqueous solution. The mineralization of calcium phosphate (CaP) on the PAA domain not only enhances the diagnostic efficacy of organic dyes, but also works as a diffusion barrier for the controlled release.
