Sensitivity of the classification of psoriatic arthritis criteria in early psoriatic arthritis
Sensitivity of the classification of psoriatic arthritis criteria in early psoriatic arthritis
复制标题
DOI：
10.1002/art.23104
复制
发表时间：
2007-12-15
期刊：
影响因子：
--
通讯作者：
Gladman, Dafna D.
中科院分区：
文献类型：
--
作者：
Chandran, Vinod;Schentag, Catherine T.;Gladman, Dafna D.
银屑病关节炎（PsA）定义为与皮肤银屑病相关的炎性关节炎，通常为类风湿因子（RF）血清阴性（1）。PsA的临床表现各不相同。患者有外周关节炎（少关节炎或多关节炎）、附着点炎、指关节炎、骶髂关节炎和脊柱炎，单独或合并发生（1）。由于缺乏有效的或广泛认同的PsA分类标准，PsA的流行病学和遗传学研究受到阻碍。虽然已经提出了一些分类标准（2），但没有一个得到广泛认可或验证（3）。最近，银屑病关节炎分类（CASPAR）研究组发布了新的银屑病关节炎分类标准，该标准来自588例银屑病关节炎患者和536例其他炎性关节炎对照患者的数据集（2）。原始研究中CASPAR标准的敏感性和特异性分别为91.4%和98.7%（2）。然而，PsA患者有长期的疾病，平均病程为12.5年。因此，建议在早期PsA中测试该标准。早期PsA的概念较新，目前对早期PsA的研究还不多。早期PsA的定义是从早期类风湿性关节炎推断出来的，通常的定义是与银屑病相关的炎性关节炎，通常RF阴性，病程2年（4，5），尽管研究使用了不同的临界值（6，7）。本研究的目的是确定CASPAR标准在早期PsA患者中的敏感性。
Psoriatic arthritis (PsA) is defined as an inflammatory arthritis associated with cutaneous psoriasis, usually seronegative for rheumatoid factor (RF)(1). The clinical presentation of PsA varies. Patients have a peripheral arthritis (oligoarthritis or polyarthritis), enthesitis, dactylitis, sacroiliitis, and spondylitis, occurring alone or in combination (1). Epidemiologic and genetic research in PsA has been hampered by the lack of validated or widely agreed upon classification criteria for PsA. Although a number of classification criteria have been proposed (2), none have been widely agreed upon or validated (3). Recently, the Classification of Psoriatic Arthritis (CASPAR) Study Group published new criteria for the classification of PsA that were derived from a data set of 588 patients with PsA and 536 controls with other inflammatory arthritis (2). The sensitivity and specificity of the CASPAR criteria in the original study were 91.4% and 98.7%, respectively (2). However, patients with PsA had longstanding disease with a mean disease duration of 12.5 years. It was therefore recommended that the criteria be tested in early PsA. The concept of early PsA is new and there have not been many studies on early PsA. The definition of early PsA has been extrapolated from early rheumatoid arthritis, and the usual definition is inflammatory arthritis associated with psoriasis, usually negative for RF with disease duration 2 years (4, 5), although studies have used varying cutoffs (6, 7). The objective of the present study was to determine the sensitivity of the CASPAR criteria in patients with early PsA.