Tumor volume reduction rate is superior to RECIST for predicting the pathological response of rectal cancer treated with neoadjuvant chemoradiation: Results from a prospective study
Tumor volume reduction rate is superior to RECIST for predicting the pathological response of rectal cancer treated with neoadjuvant chemoradiation: Results from a prospective study
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DOI：
10.3892/ol.2015.3101
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发表时间：
2015-06-01
期刊：
影响因子：
2.9
通讯作者：
Wang, Jianping
中科院分区：
文献类型：
--
作者：
Xiao, Han;Tan, Yuting;Wang, Jianping
本研究的目的是比较三维感兴趣区磁共振体积测定法测定的肿瘤体积缩小率（TVRR）和实体瘤疗效评价标准（RECIST）数据，以预测局部晚期直肠癌（LARC）接受新辅助放化疗（CRT）治疗后的病理学肿瘤缓解（PTR）。当前队列包括来自一项前瞻性随机试验的105例LARC [临床肿瘤分期（cT）3-4或临床淋巴结分期（cN）+]患者，这些患者接受了术前CRT和根治性直肠切除术。在CRT之前和之后测量肿瘤体积以确定TVRR。此外，建立TVRR和RECIST的受试者工作特征（ROC）曲线，以预测肿瘤消退等级（TRG）和降级方面的PTR。比较ROC曲线下面积（AUC）的值，并确定TVRR截止值。使用RECIST确定5例（4.8%）完全缓解，44例（41.9%）部分缓解，55例（52.4%）疾病稳定，1例（0.9%）疾病进展。平均TVRR为58.6 - 24.4%，TRG（0-1）和降级分别为54（51.4%）和59（56.2%）例。此外，TVRR和RECIST与TRG和降级显著相关（P
The aim of the present study was to compare the tumor volume reduction rate (TVRR), as determined by three-dimensional region-of-interest magnetic resonance volumetry, and Response Evaluation Criteria in Solid Tumors (RECIST) data for predicting the pathological tumor response (PTR) of locally advanced rectal cancer (LARC) following treatment with neoadjuvant chemoradiation (CRT). The current cohort consisted of 105 patients with LARC [clinical tumor stage (cT)3-4 or clinical lymph node stage (cN)+] from a prospective randomized trial who had undergone pre-operative CRT and radical proctectomy. Tumor volumes were measured prior to and following CRT to determine TVRR. Furthermore, receiver operating characteristic (ROC) curves of TVRR and RECIST were constructed to predict the PTR in terms of tumor regression grade (TRG) and downstaging. Values for the area under the ROC curve (AUC) were compared and TVRR cut-off levels were determined. RECIST was used to identify 5 (4.8%) cases of complete response, 44 (41.9%) of partial response, 55 (52.4%) of stable disease and 1 (0.9%) of progressive disease. The mean TVRR was 58.6 24.4%, and a good TRG (0-1) and downstaging occurred in 54(51.4%) and 59 (56.2%) patients, respectively. In addition, TVRR and RECIST were significantly correlated with TRG and downstaging (P